iPTMnet Report for P37231 (PPARG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P37231 / PPARG_HUMAN
Protein Name Peroxisome proliferator-activated receptor gamma
Gene Name Name: PPARG
Synonyms:NR1C3;
Organism Homo sapiens (Human)

PRO ID PR:P37231
DAG View
PRO Name peroxisome proliferator-activated receptor gamma (human)
Definition A peroxisome proliferator-activated receptor gamma that is encoded in the genome of human.
Short Label hPPARG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P37231 (PPARG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y78 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
K107 Sumoylation PhosphoSitePlus
S112 Phosphorylation P27361 (MAPK3) , P50750 (CDK9) , P45983 (MAPK8) , P50613 (CDK7) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17998334, 23320500, 23186163, ...11733495, 9030579, 33567272, 15988019, 24096891, 24810249, 18981214
T166 Phosphorylation PhosphoSitePlus   RLIMS-P 36329235
K184 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K268 Acetylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
S273 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P 23320500, 27974179, 20651683, ...27027223, 33329381, 33142057, 24810249, 29295932, 28811832, 25734377, 21691811, 24692390, 29056962, 30199253, 21892191
K293 Acetylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K395 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S112 Phosphorylation P45983 (MAPK8) , P28482 (MAPK1) HPRD 9030579
T269 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
Y74 Phosphorylation P00533 (EGFR) PhosphoSitePlus 26718225
K79 Sumoylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
K367 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S84 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K185 E185 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K395 R395 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]