iPTMnet Report for P37173 (TGFBR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P37173 / TGFR2_HUMAN
Protein Name TGF-beta receptor type-2 precursor
Gene Name Name: TGFBR2
Organism Homo sapiens (Human)

PRO ID PR:P37173
DAG View
PRO Name TGF-beta receptor type-2 (human)
Definition A TGF-beta receptor type-2 that is encoded in the genome of human.
Short Label hTGFBR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P37173 (TGFBR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 O-Glycosylation PhosphoSitePlus
T39 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N70 N-Glycosylation GlyGen 24190977
N94 N-Glycosylation GlyGen 29391424
K205 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S213 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155023
S213 Phosphorylation P37173 (TGFBR2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155023
Y259 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 9169454
Y259 Phosphorylation P37173 (TGFBR2) neXtProt   phospho.ELM   PhosphoSitePlus 9169454
K260 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
N266 N-Glycosylation GlyGen 29391424
Y284 Phosphorylation IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17440088, 19114990
Y284 Phosphorylation P12931 (SRC) neXtProt   PhosphoSitePlus   Signor 17440088, 19114990
K291 Ubiquitination PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 9169454
Y336 Phosphorylation P37173 (TGFBR2) neXtProt   phospho.ELM   PhosphoSitePlus 9169454
S352 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S409 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9155023
S409 Phosphorylation P37173 (TGFBR2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155023
S416 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9155023
S416 Phosphorylation P37173 (TGFBR2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155023
Y424 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 9169454
Y424 Phosphorylation P37173 (TGFBR2) neXtProt   phospho.ELM   PhosphoSitePlus 9169454
T445 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
S548 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...24275569
S551 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
N564 N-Glycosylation GlyGen 29391424
T566 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S213 Phosphorylation HPRD   PRO 9155023
S213 Phosphorylation P37173 (TGFBR2) HPRD 9155023
S225 Phosphorylation HPRD 8947046
S228 Phosphorylation HPRD 8947046
S229 Phosphorylation HPRD 8947046
Y259 Phosphorylation HPRD   PRO 9169454
Y336 Phosphorylation HPRD   PRO 9169454
S409 Phosphorylation HPRD   PRO 9155023
S409 Phosphorylation P37173 (TGFBR2) HPRD 9155023
S416 Phosphorylation HPRD 9169454
S416 Phosphorylation P37173 (TGFBR2) HPRD 9169454
Y424 Phosphorylation HPRD   PRO 9169454
S548 Phosphorylation HPRD 18691976, 18578522, 17081983
S551 Phosphorylation HPRD 8947046
S553 Phosphorylation HPRD 8947046
S562 Phosphorylation HPRD 18578522
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
S238 Phosphorylation HPRD 9155023
S238 Phosphorylation P37173 (TGFBR2) HPRD 9155023
S250 Phosphorylation HPRD 8947046
S253 Phosphorylation HPRD 8947046
S254 Phosphorylation HPRD 8947046
Y284 Phosphorylation HPRD 9169454
Y361 Phosphorylation HPRD 9169454
S434 Phosphorylation HPRD 9155023
S434 Phosphorylation P37173 (TGFBR2) HPRD 9155023
S441 Phosphorylation HPRD 9169454
S441 Phosphorylation P37173 (TGFBR2) HPRD 9169454
Y449 Phosphorylation HPRD 9169454
S573 Phosphorylation HPRD 18691976, 18578522, 17081983
S576 Phosphorylation HPRD 8947046
S578 Phosphorylation HPRD 8947046
S587 Phosphorylation HPRD 18578522


P37173 (TGFBR2) as PTM Enzyme



Substrate Site Score Source PMID
P17813 (ENG) S634 neXtProt   PhosphoSitePlus 16785228
P17813 (ENG) S635 neXtProt   PhosphoSitePlus 16785228
P36897 (TGFBR1) S165 neXtProt 8947046
P36897 (TGFBR1) S172 HPRD   Signor 8576253
P36897 (TGFBR1) T176 HPRD   Signor 8576253
P36897 (TGFBR1) T185 neXtProt   PhosphoSitePlus 7774578, 8947046
P36897 (TGFBR1) T186 neXtProt   PhosphoSitePlus 7774578, 8947046
P36897 (TGFBR1) S187 neXtProt   PhosphoSitePlus 7774578, 8947046
P36897 (TGFBR1) S189 neXtProt   PhosphoSitePlus 7774578, 8947046
P36897 (TGFBR1) S191 neXtProt   PhosphoSitePlus 7774578, 8947046
P37173 (TGFBR2) S213 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155023
P37173-2 (TGFBR2) S238 HPRD 9155023
P37173 (TGFBR2) Y259 neXtProt   phospho.ELM   PhosphoSitePlus 9169454
P37173 (TGFBR2) Y336 neXtProt   phospho.ELM   PhosphoSitePlus 9169454
P37173 (TGFBR2) S409 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9155023
P37173-1 (TGFBR2) S416 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9169454, 9155023
P37173 (TGFBR2) Y424 neXtProt   phospho.ELM   PhosphoSitePlus 9169454
P37173-2 (TGFBR2) S434 HPRD 9155023
P37173-2 (TGFBR2) S441 HPRD 9169454
Q03167 (TGFBR3) T843 neXtProt 11323414, 12958365
Q9NPB6 (PARD6A) S345 neXtProt   Signor 23249950, 15761148
PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025959 (hTGFBR1/iso:1/SigPep-/Phos:1) pS165,pT185,pT186,pS187,pS189,pS191 PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1) PRO 7774578, 8947046


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1) pS213,pY259,pY336,pS409,pY424 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43683 (BUB1) S318 P37173 (TGFBR2) unknown eFIP 32143140


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036408 (hTGFBR2/iso:RII-1/SigPep-) Interaction PR:000000616 (TGFB1/iso:1/mature) PRO 1310899
PR:000036408 (hTGFBR2/iso:RII-1/SigPep-) Interaction PR:000000634 (TGFB3/iso:1/Clv:1) PRO 1850637


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T39 I39 Biomuta DOID:1319 / brain cancer [ cosmic ]
S213 I213 Biomuta DOID:3571 / liver cancer [ cosmic ]
S228 N228 Biomuta DOID:1319 / brain cancer [ cosmic ]
S238 I238 Biomuta DOID:3571 / liver cancer [ cosmic ]
S253 N253 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y259 D259 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y284 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y284 D284 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K291 E291 Biomuta [ cosmic ]
Y336 C336 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y361 C361 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K381 N381 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K381 E381 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K381 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S409 F409 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y424 D424 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y424 C424 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S434 F434 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y449 D449 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y449 C449 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y470 D470 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S553 T553 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
K556 E556 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S562 F562 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
N564 S564 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N564 H564 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S578 T578 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S587 F587 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]