iPTMnet Report for P37088 (SCNN1A)
Protein Information
UniProt AC / UniProt ID | P37088 / SCNNA_HUMAN |
Protein Name | Amiloride-sensitive sodium channel subunit alpha |
Gene Name | Name: SCNN1A Synonyms:SCNN1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P37088 |
PRO Name | amiloride-sensitive sodium channel subunit alpha (human) |
Definition | An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human. |
Short Label | hSCNN1A |
Category | organism-gene |
P37088 (SCNN1A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Ubiquitination | score1 | PRO | ||||
K22 | Ubiquitination | score1 | PhosphoSitePlus | |||
T154 | Phosphorylation | score1 | PhosphoSitePlus | |||
S174 | Phosphorylation | score1 | PhosphoSitePlus | |||
K220 | Ubiquitination | score1 | PhosphoSitePlus | |||
K233 | Ubiquitination | score1 | PhosphoSitePlus | |||
T375 | Phosphorylation | score1 | PhosphoSitePlus | |||
S376 | Phosphorylation | score1 | PhosphoSitePlus | |||
S378 | Phosphorylation | score1 | PhosphoSitePlus | |||
T383 | Phosphorylation | score1 | PhosphoSitePlus | |||
S399 | O-Glycosylation | score1 | GlyGen | 35289036 | ||
K529 | Ubiquitination | score1 | PhosphoSitePlus | |||
S594 | Phosphorylation | score1 | PhosphoSitePlus | |||
T663 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 16174865 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000049168 (hSCNN1A/UbiqLys+) | ub | PRO |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S174 | F174 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S174 | P174 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K220 | R220 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K220 | N220 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T375 | N375 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S594 | F594 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
T663 | I663 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T663 | A663 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |