iPTMnet Report P36897 TGFBR1

UniProt AC / UniProt ID	P36897 / TGFR1_HUMAN
Protein Name	TGF-beta receptor type-1 precursor
Gene Name	Name: TGFBR1 Synonyms:ALK5,SKR4;
Organism	Homo sapiens (Human)

PRO ID	PR:P36897 DAG View
PRO Name	TGF-beta receptor type-1 (human)
Definition	A TGF-beta receptor type-1 that is encoded in the genome of human.
Short Label	hTGFBR1
Category	organism-gene

	Select/align proteoforms across species

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Ubiquitination		score1	PRO
S165	Phosphorylation	P37173 (TGFBR2)	score4	neXtProt PhosphoSitePlus RLIMS-P UniProt	19369195, 29572483, 8947046
S172	Phosphorylation	P37173 (TGFBR2)	score3	PhosphoSitePlus Signor	8576253
T176	Phosphorylation	P37173 (TGFBR2)	score3	PhosphoSitePlus Signor	8576253
K178	Ubiquitination		score1	PhosphoSitePlus
Y182	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	36378749
T185	Phosphorylation	P37173 (TGFBR2)	score4	neXtProt PhosphoSitePlus UniProt	7774578, 8947046
T186	Phosphorylation	P37173 (TGFBR2)	score4	neXtProt PhosphoSitePlus UniProt	7774578, 8947046
S187	Phosphorylation	P37173 (TGFBR2)	score4	neXtProt PhosphoSitePlus UniProt	7774578, 8947046
S189	Phosphorylation	P37173 (TGFBR2)	score4	neXtProt PhosphoSitePlus UniProt	7774578, 8947046
S191	Phosphorylation	P37173 (TGFBR2)	score4	neXtProt PhosphoSitePlus UniProt	7774578, 8947046
T200	Phosphorylation	P17252 (PRKCA)	score3	neXtProt PhosphoSitePlus	23290522
T204	Phosphorylation		score1	PhosphoSitePlus
S210	Phosphorylation		score1	PhosphoSitePlus
T298	Phosphorylation		score1	PhosphoSitePlus
K337	Ubiquitination		score1	PhosphoSitePlus
K391	Ubiquitination		score1	PhosphoSitePlus
K449	Ubiquitination		score1	PhosphoSitePlus
C461	Methylation		score1	IEDB	31844290
C474	Methylation		score1	IEDB	31844290
K490	Ubiquitination		score1	PhosphoSitePlus
K502	Ubiquitination		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S165	Phosphorylation	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	score3	PRO	7774578, 8947046
S172	Phosphorylation	P37173 (TGFBR2)	score1	HPRD	8576253
T176	Phosphorylation	P37173 (TGFBR2)	score1	HPRD	8576253
T185	Phosphorylation	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	score3	PRO	7774578, 8947046
T186	Phosphorylation	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	score3	PRO	7774578, 8947046
S187	Phosphorylation	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	score3	PRO	7774578, 8947046
S189	Phosphorylation	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	score3	PRO	7774578, 8947046
S191	Phosphorylation	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	score3	PRO	7774578, 8947046
Y295	Phosphorylation		score0	HPRD	20068231
T298	Phosphorylation		score0	HPRD	20068231

Substrate	Site	Score	Source	PMID
P17813 (ENG)	S646	score3	neXtProt PhosphoSitePlus	20042635
P17813 (ENG)	S649	score3	neXtProt PhosphoSitePlus	20042635
P68104 (EEF1A1)	S300	score3	neXtProt PhosphoSitePlus Signor	20832312
P84022 (SMAD3)	S422	score2	neXtProt	9380693
P84022 (SMAD3)	S423	score2	neXtProt	9380693
P84022 (SMAD3)	S425	score2	neXtProt	9380693
Q03167 (TGFBR3)	S831	score2	PhosphoSitePlus	22427868
Q15796 (SMAD2)	S464	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	9346908, 9892009, 8980228
Q15796-1 (SMAD2)	S465	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	9346908, 9892009, 15134444, ...8980228
Q15796 (SMAD2)	S467	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	9346908, 9892009, 15134444, ...8980228
Q15797-1 (SMAD1)	S462	score2	HPRD	9748228, 9136927, 10085121
Q15797-1 (SMAD1)	S463	score2	HPRD	19651622, 9748228, 9136927, ...10085121
Q15797-1 (SMAD1)	S465	score2	HPRD	19651622, 9748228, 9136927, ...10085121
Q96FW1 (OTUB1)	S18	score2	PhosphoSitePlus	25872870
Q9H3D4-2 (TP63)	S66	score2	PhosphoSitePlus	23166821
Q9H3D4 (TP63)	S68	score3	PhosphoSitePlus Signor	23166821
Q9H3D4 (TP63)	S160	score1	Signor	23166821

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000049433 (hTGFBR1/SigPep-/UbiqLys+)	ub		PRO
	PR:000025959 (hTGFBR1/iso:1/SigPep-/Phos:1)	pS165,pT185,pT186,pS187,pS189,pS191	PR:000025962 (hTGFBR2/iso:RII-1/SigPep-/Phos:1)	PRO	7774578, 8947046

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	O43683 (BUB1)	S318	P36897 (TGFBR1)	unknown	eFIP	32143140

	Protein 1	Relation	Protein 2	Source	PMID
	PR:P84022-1 (hSMAD3/iso:1)	Interaction	PR:000025959 (hTGFBR1/iso:1/SigPep-/Phos:1)	PRO	12154125

Site	Variant	Source	Disease [Sample source]
S165	*	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
T176	M176	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
Y182	*	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
Y182	C182	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T186	A186	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T186	M186	Biomuta	DOID:9256 / colorectal cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S187	*	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
Y295	F295	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T298	I298	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K391	N391	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K449	N449	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]

Or input other organisms

iPTMnet Report for P36897 (TGFBR1)