iPTMnet Report for P36896 (ACVR1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P36896 / ACV1B_HUMAN
Protein Name Activin receptor type-1B precursor
Gene Name Name: ACVR1B
Synonyms:ACVRLK4,ALK4;
Organism Homo sapiens (Human)

PRO ID PR:P36896
DAG View
PRO Name activin receptor type-1B (human)
Definition An activin receptor type-1B that is encoded in the genome of human.
Short Label hACVR1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36896 (ACVR1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K80 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PRO
T188 Phosphorylation PRO
S189 Phosphorylation PRO
S191 Phosphorylation PRO
S193 Phosphorylation PRO
T206 Phosphorylation PRO   PhosphoSitePlus   Signor 8622651
T206 Phosphorylation Q13705 (ACVR2B) Signor 8622651
K215 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
Y380 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 12112843
K393 Ubiquitination PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y380 Phosphorylation HPRD   PRO 12112843
Site PTM Type PTM Enzyme Score Source PMID
K468 Ubiquitination PhosphoSitePlus


P36896 (ACVR1B) as PTM Enzyme



Substrate Site Score Source PMID
O95551 (TDP2) T88 neXtProt   PhosphoSitePlus   Signor 18039968
O95551 (TDP2) T92 neXtProt   PhosphoSitePlus   Signor 18039968
Q15796-1 (SMAD2) S464 HPRD 9892009
Q15796-1 (SMAD2) S465 HPRD 9892009
Q15796-1 (SMAD2) S467 HPRD 9892009


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046257 (hACVR1B/SigPep-/Phos:3) pS187,pT188,pS189,pS191,pS193,pT206 PRO
PR:000036438 (hACVR1B/iso:1/Phos:2) pY380 PRO 12112843


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036437 (hACVR1B/iso:1/Phos:1) Interaction PR:000000066 (R-SMAD(TGFB)) PRO 12065756


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S168 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S189 L189 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S189 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S191 Y191 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K339 N339 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K345 N345 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y380 N380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y380 C380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]