Protein Information

Cytoscape View


UniProt AC / UniProt ID P36888 / FLT3_HUMAN
Protein Name Receptor-type tyrosine-protein kinase FLT3 precursor
Gene Name Name: FLT3
Synonyms:CD135,FLK2,STK1;
Organism Homo sapiens (Human)

PRO ID PR:P36888
DAG View
PRO Name receptor-type tyrosine-protein kinase FLT3 (human)
Definition A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.
Short Label hFLT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36888 (FLT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N43 N-Glycosylation GlyGen   UniProt 21389326
N100 N-Glycosylation GlyGen   UniProt 21389326
N151 N-Glycosylation GlyGen   UniProt 21389326
Y166 Phosphorylation PhosphoSitePlus
N306 N-Glycosylation GlyGen   UniProt 21389326
N323 N-Glycosylation GlyGen   UniProt 21389326
T343 Phosphorylation PhosphoSitePlus
N351 N-Glycosylation GlyGen   UniProt 21389326
N354 N-Glycosylation GlyGen   UniProt 21389326
Y416 Phosphorylation PhosphoSitePlus
Y566 Phosphorylation IntAct 27458164
Y572 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16684964, 27458164, 21262971, ...23246379
S574 Phosphorylation neXtProt   UniProt 16684964
Y589 Phosphorylation P36888 (FLT3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19276253, 19477218, 9737679, ...22411868, 21262971, 16684964, 27458164, 11971190
Y591 Phosphorylation P36888 (FLT3) , P11309 (PIM1) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 24608088, 24040307, 15831474, ...16627759, 25640477, 19477218, 22411868, 16684964, 21262971, 31606550, 22952242, 26601252, 27458164, 33363015, 11971190
Y597 Phosphorylation P36888 (FLT3) phospho.ELM   PhosphoSitePlus   Signor 11971190
Y599 Phosphorylation P36888 (FLT3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19276253, 19477218, 21262971, ...16684964, 27458164, 11971190
K602 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
Y726 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28086240, 16627759, 19477218, ...21552520, 27458164
T728 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y768 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   UniProt 19477218, 21262971, 19438505
K772 Ubiquitination PhosphoSitePlus
Y793 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28086240, 23246379, 19477218, ...21262971, 27458164
S840 Phosphorylation PhosphoSitePlus
Y842 Phosphorylation P36888 (FLT3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28086240, 16627759, 19477218, ...21262971, 15345593, 21552520
Y919 Phosphorylation IntAct   RLIMS-P 22952242, 27458164, 33363015
K932 Ubiquitination PhosphoSitePlus
S935 Phosphorylation RLIMS-P 26601252
Y955 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   UniProt 19438505, 19477218, 21262971, ...27458164, 16627759
T968 Phosphorylation PhosphoSitePlus
Y969 Phosphorylation P36888 (FLT3) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16627759, 21552520, 27458164, ...31217189, 19438505
S993 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
Y589 Phosphorylation P36888 (FLT3) HPRD 11971190
Y591 Phosphorylation P36888 (FLT3) HPRD 11971190
Y597 Phosphorylation P36888 (FLT3) HPRD 11971190
Y599 Phosphorylation P36888 (FLT3) HPRD 11971190


P36888 (FLT3) as PTM Enzyme



Substrate Site Score Source PMID
P24752 (ACAT1) Y407 Signor 34289383
P29353-7 (SHC1) Y239 HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
P29353-7 (SHC1) Y240 HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
P29353-7 (SHC1) Y318 HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P29353 (SHC1) Y349 Signor 10482988
P29353 (SHC1) Y350 Signor 10482988
P29353 (SHC1) Y427 Signor 10482988
P35222 (CTNNB1) Y654 RLIMS-P+ 22126602
P36888 (FLT3) Y572 neXtProt 16684964
P36888 (FLT3) Y589 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16684964, 19477218, 9737679, ...22411868, 11971190
P36888 (FLT3) Y591 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15831474, 16627759, 19477218, ...22411868, 16684964, 11971190
P36888-1 (FLT3) Y597 HPRD   phospho.ELM   Signor 11971190
P36888 (FLT3) Y599 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16684964, 19477218, 11971190
P36888 (FLT3) Y726 neXtProt   PhosphoSitePlus   UniProt 19477218, 16627759
P36888 (FLT3) Y768 neXtProt 19477218, 19438505
P36888 (FLT3) Y793 neXtProt 19477218
P36888 (FLT3) Y842 neXtProt   PhosphoSitePlus   UniProt 19477218, 16627759
P36888 (FLT3) Y955 neXtProt   PhosphoSitePlus   UniProt 19477218, 19438505, 16627759
P36888 (FLT3) Y969 neXtProt   PhosphoSitePlus   UniProt 16627759, 19438505
P48735 (IDH2) Y107 Signor 34289383
Q15118 (PDK1) Y243 neXtProt   PhosphoSitePlus 22195962


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P36888 (FLT3) Y842 Q9HBL0 (TNS1) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y726 P42684 (ABL2) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y842 P43405 (SYK) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y842 P51451 (BLK) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y793 P06239 (LCK) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y793 P00519 (ABL1) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y793 Q8R4L0 (Sla2) unknown eFIP 27458164
Phosphorylation P36888 (FLT3) Y793 P06241 (FYN) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y793 P46109 (CRKL) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y793 P20936 (RASA1) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y793 Q13322 (GRB10) unknown eFIP 23246379
Phosphorylation P36888 (FLT3) Y793 P46108 (CRK) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y589 Q06124 (PTPN11) unknown eFIP 16684964
Phosphorylation P36888 (FLT3) Y726 P07947 (YES1) unknown eFIP 28086240
Phosphorylation P36888 (FLT3) Y842 O14544 (SOCS6) unknown eFIP 28086240