Protein Information

Cytoscape View


UniProt AC / UniProt ID P36888 / FLT3_HUMAN
Protein Name Receptor-type tyrosine-protein kinase FLT3 precursor
Gene Name Name: FLT3
Synonyms:CD135,FLK2,STK1;
Organism Homo sapiens (Human)

PRO ID PR:P36888
DAG View
PRO Name receptor-type tyrosine-protein kinase FLT3 (human)
Definition A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human.
Short Label hFLT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36888 (FLT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N43 N-Glycosylation UniProt 21389326
N100 N-Glycosylation UniProt 21389326
N151 N-Glycosylation UniProt 21389326
Y166 Phosphorylation PhosphoSitePlus
N306 N-Glycosylation UniProt 21389326
N323 N-Glycosylation UniProt 21389326
T343 Phosphorylation PhosphoSitePlus
N351 N-Glycosylation UniProt 21389326
N354 N-Glycosylation UniProt 21389326
Y416 Phosphorylation PhosphoSitePlus
Y572 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16684964, 22942183, 21262971
S574 Phosphorylation neXtProt   UniProt 16684964
Y589 Phosphorylation P36888 (FLT3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19276253, 19477218, 9737679, ...22411868, 21262971, 16684964, 27458164, 11971190
Y591 Phosphorylation P36888 (FLT3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24040307, 22942183, 16627759, ...25640477, 19477218, 22411868, 16684964, 15831474, 21262971, 22952242, 26601252, 27458164, 11971190
Y597 Phosphorylation P36888 (FLT3) phospho.ELM   PhosphoSitePlus   Signor 11971190
Y599 Phosphorylation P36888 (FLT3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19276253, 19477218, 21262971, ...16684964, 11971190
K602 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
Y726 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19477218, 21552520, 16627759
T728 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y768 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   UniProt 19477218, 21262971, 19438505
K772 Ubiquitination PhosphoSitePlus
Y793 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 19477218, 21262971
S840 Phosphorylation PhosphoSitePlus
Y842 Phosphorylation P36888 (FLT3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16627759, 19477218, 21262971, ...21552520, 15345593
Y919 Phosphorylation RLIMS-P 22952242, 22942183
K932 Ubiquitination PhosphoSitePlus
S935 Phosphorylation RLIMS-P 26601252
Y955 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   UniProt 19477218, 21262971, 19438505, ...16627759
T968 Phosphorylation PhosphoSitePlus
Y969 Phosphorylation P36888 (FLT3) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 21552520, 16627759, 19438505
S993 Phosphorylation PhosphoSitePlus   UniProt 19369195
Site PTM Type PTM Enzyme Score Source PMID
Y589 Phosphorylation P36888 (FLT3) HPRD 11971190
Y591 Phosphorylation P36888 (FLT3) HPRD 11971190
Y597 Phosphorylation P36888 (FLT3) HPRD 11971190
Y599 Phosphorylation P36888 (FLT3) HPRD 11971190


P36888 (FLT3) as PTM Enzyme



Substrate Site Score Source PMID
P29353-7 (SHC1) Y239 HPRD 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 20068231, 16497976
P29353-7 (SHC1) Y240 HPRD 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 20068231, 16497976
P29353-7 (SHC1) Y318 HPRD 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P36888 (FLT3) Y572 neXtProt 16684964
P36888 (FLT3) Y589 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16684964, 19477218, 9737679, ...22411868, 11971190
P36888 (FLT3) Y591 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15831474, 16627759, 19477218, ...22411868, 16684964, 11971190
P36888 (FLT3) Y597 HPRD   phospho.ELM   Signor 11971190
P36888-1 (FLT3) Y599 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16684964, 19477218, 11971190
P36888 (FLT3) Y726 neXtProt   PhosphoSitePlus   UniProt 19477218, 16627759
P36888 (FLT3) Y768 neXtProt 19477218, 19438505
P36888 (FLT3) Y793 neXtProt 19477218
P36888 (FLT3) Y842 neXtProt   PhosphoSitePlus   UniProt 19477218, 16627759
P36888 (FLT3) Y955 neXtProt   PhosphoSitePlus   UniProt 19477218, 19438505, 16627759
P36888 (FLT3) Y969 neXtProt   PhosphoSitePlus   UniProt 16627759, 19438505
Q15118 (PDK1) Y243 neXtProt   PhosphoSitePlus   UniProt 22195962


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P36888 (FLT3) Y919 Q9UQQ2 (SH2B3) unknown eFIP 22942183
Phosphorylation P36888 (FLT3) Y591 Q9UQQ2 (SH2B3) unknown eFIP 22942183
Phosphorylation P36888 (FLT3) Y572 Q9UQQ2 (SH2B3) unknown eFIP 22942183