iPTMnet Report for P36776 (LONP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P36776 / LONM_HUMAN
Protein Name Lon protease homolog, mitochondrial precursor
Gene Name Name: LONP1
Synonyms:PRSS15;
Organism Homo sapiens (Human)

PRO ID PR:P36776
DAG View
PRO Name Lon protease homolog, mitochondrial (human)
Definition A Lon protease, mitochondrial that is encoded in the genome of human.
Short Label hLONP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36776 (LONP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
Y7 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S173 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P   Signor 31406245
S181 Phosphorylation P31749 (AKT1) PhosphoSitePlus   Signor 31406245
Y186 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S343 Phosphorylation IEDB 35494241
K361 Acetylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
K393 Acetylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K411 Acetylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
T580 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
K690 Acetylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
C704 Methylation IEDB 31844290
K714 Ubiquitination PhosphoSitePlus
R904 Methylation PhosphoSitePlus
K917 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T803 Phosphorylation HPRD 20068231
T880 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S80 L80 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:1781 / thyroid cancer [ icgc ]
S313 L313 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T580 A580 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S693 L693 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K714 N714 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]