iPTMnet Report for P36507 (MAP2K2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P36507 / MP2K2_HUMAN
Protein Name Dual specificity mitogen-activated protein kinase kinase 2
Gene Name Name: MAP2K2
Synonyms:MEK2,MKK2,PRKMK2;
Organism Homo sapiens (Human)

PRO ID PR:P36507
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 2 (human)
Definition A dual specificity mitogen-activated protein kinase kinase 2 that is encoded in the genome of human.
Short Label hMAP2K2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36507 (MAP2K2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K6 Ubiquitination PhosphoSitePlus
T13 Acetylation PhosphoSitePlus
T13 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 33226073, 32574038, ...34725712, 30059200, 29351928, 31492838, 20563614, 32119511, 34229054
T13 Phosphorylation RLIMS-P 33226073
T17 O-Glycosylation GlyGen 33226073
S23 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 18669648, ...24275569, 20068231
T25 Phosphorylation HPRD 18691976
S26 Phosphorylation HPRD   PhosphoSitePlus 17192257
S26 Phosphorylation P36507 (MAP2K2) HPRD 17192257
S30 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus 21851590
T59 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K61 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K108 Sumoylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S216 Phosphorylation phospho.ELM   PhosphoSitePlus 12506122
S222 Acetylation PhosphoSitePlus
S222 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17667937, 17210721, 26242183, ...8157000, 17116858, 18669648, 15466476, 19804365, 15175348, 8668348, 10409742, 20068231
S222 Phosphorylation O15530 (PDPK1) neXtProt 15175348
S222 Phosphorylation P04049 (RAF1) Signor 8157000
S222 Phosphorylation P15056 (BRAF) neXtProt   PhosphoSitePlus   Signor 17667937, 17210721, 8668348
S222 Phosphorylation P41279 (MAP3K8) phospho.ELM   PhosphoSitePlus   Signor 15466476, 19804365
S222 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26242183
S226 Acetylation PhosphoSitePlus
S226 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17667937, 17210721, 26242183, ...8157000, 17116858, 17192257, 18669648, 15466476, 19804365, 15175348, 8668348, 20068231
S226 Phosphorylation O15530 (PDPK1) neXtProt   PhosphoSitePlus   Signor 15175348
S226 Phosphorylation P04049 (RAF1) Signor 8157000
S226 Phosphorylation P15056 (BRAF) neXtProt   PhosphoSitePlus   Signor 17667937, 17210721, 8668348
S226 Phosphorylation P36507 (MAP2K2) HPRD 18669648, 17192257, 20068231
S226 Phosphorylation P41279 (MAP3K8) phospho.ELM   PhosphoSitePlus   Signor 15466476, 19804365
S226 Phosphorylation P53350 (PLK1) PhosphoSitePlus 26242183
T230 Phosphorylation HPRD   PhosphoSitePlus 20068231
S293 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
S295 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18220336, 18452278, ...19651622, 20068231
S306 Phosphorylation neXtProt   PhosphoSitePlus 9416003
S312 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
S372 Phosphorylation HPRD   PhosphoSitePlus 20068231
C384 Methylation IEDB 31844290
K385 Ubiquitination PhosphoSitePlus
T394 O-Glycosylation GlyGen 32574038
T394 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 33226073, 23186163, ...18212344, 18691976, 15302935, 19651622, 21406692, 17192257, 17322306, 18669648, 20166139, 18088087, 19574224, 19415658, 20068231, 17081983
T396 O-Glycosylation GlyGen 23301498, 33226073, 32574038, ...34725712, 30059200, 29351928, 31492838, 20563614, 32119511, 34229054
T396 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 18088087, ...16964243, 19651622, 17322306, 18669648, 24275569, 20166139, 23186163, 20068231
T396 Phosphorylation P36507 (MAP2K2) HPRD 18691976, 18088087, 16964243, ...19651622, 17322306, 18669648, 20166139, 20068231
T398 O-Glycosylation GlyGen 23301498, 33226073, 32574038, ...34725712, 30059200, 29351928, 31492838, 20563614, 32119511, 34229054
T398 Phosphorylation PhosphoSitePlus


P36507 (MAP2K2) as PTM Enzyme



Substrate Site Score Source PMID
P05787 (KRT8) S74 PhosphoSitePlus 15939799
P27361 (MAPK3) T202 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18691976, 17389395, 16585161, ...7687743, 19651622, 1411546, 18669648, 8626767, 15939799, 8226933
P27361-1 (MAPK3) Y204 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19901323, 15580310, 17389395, ...18691976, 1411546, 19651622, 18669648, 8626767, 15939799, 8226933, 16585161, 18707149, 20068231, 16497976
P28482 (MAPK1) T185 neXtProt   Signor 11971971, 21365009, 8226933
P28482 (MAPK1) Y187 neXtProt   Signor 11971971, 21365009, 8226933
P36507 (MAP2K2) S26 HPRD 17192257
P36507 (MAP2K2) S226 HPRD 18669648, 17192257, 20068231
P36507 (MAP2K2) T396 HPRD 18691976, 18088087, 16964243, ...19651622, 17322306, 18669648, 20166139, 20068231
P55211-1 (CASP9) T125 HPRD 12792650, 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048296 (hMAP2K2/Phos:2) pS222,pS226 PRO