iPTMnet Report for P35991 (Btk)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35991 / BTK_MOUSE
Protein Name Tyrosine-protein kinase BTK
Gene Name Name: Btk
Synonyms:Bpk;
Organism Mus musculus (Mouse)

PRO ID PR:P35991
DAG View
PRO Name tyrosine-protein kinase BTK (mouse)
Definition A tyrosine-protein kinase BTK that is encoded in the genome of mouse.
Short Label mBTK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35991 (Btk) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus   UniProt 17947660
S115 Phosphorylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus 11598012
T191 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation P35991 (Btk) , O35904 (Pik3cd) PRO   PhosphoSitePlus   RLIMS-P   UniProt 29263930, 28359287, 33162995, ...23544144, 26059659, 30635655, 33639170, 29069762, 28368423, 8630736, 30646846, 9391111, 9326643, 31552054
Y225 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
Y344 Phosphorylation PhosphoSitePlus   UniProt 17947660
Y345 Phosphorylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation P35991 (Btk) PhosphoSitePlus 16291652
Y425 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation P35991 (Btk) , O35904 (Pik3cd) PRO   PhosphoSitePlus   RLIMS-P   UniProt 28359287, 17947660, 9391111, ...29069762, 8629002, 28368423, 7565679, 14634110, 9326643
S553 Phosphorylation PhosphoSitePlus
Y617 Phosphorylation P35991 (Btk) PhosphoSitePlus 15375214
S623 Phosphorylation PhosphoSitePlus


P35991 (Btk) as PTM Enzyme



Substrate Site Score Source PMID
P35991 (Btk) Y223 UniProt 8630736
P35991 (Btk) Y375 PhosphoSitePlus 16291652
P35991 (Btk) Y551 PhosphoSitePlus 7565679
P35991 (Btk) Y617 PhosphoSitePlus 15375214
P42230 (Stat5a) Y694 PhosphoSitePlus 11413148
Q03267 (Ikzf1) S213 PhosphoSitePlus 23977012
Q03267 (Ikzf1) S214 PhosphoSitePlus 23977012


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000037482 (mBTK/Phos:1) pY223,pY551 PRO 9326643


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35991 (Btk) Y223 Q8R4B8 (Nlrp3) unknown eFIP 26059659