iPTMnet Report for P35916 (FLT4)
Protein Information
| UniProt AC / UniProt ID | P35916 / VGFR3_HUMAN |
| Protein Name | Vascular endothelial growth factor receptor 3 precursor |
| Gene Name | Name: FLT4 Synonyms:VEGFR3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P35916 |
| PRO Name | vascular endothelial growth factor receptor 3 (human) |
| Definition | A vascular endothelial growth factor receptor 3 that is encoded in the genome of human. |
| Short Label | hFLT4 |
| Category | organism-gene |
DAG ViewP35916 (FLT4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| N33 | N-Glycosylation | score3 | GlyGen UniProt | 23878260 | ||
| N104 | N-Glycosylation | score3 | GlyGen UniProt | 23878260 | ||
| N411 | N-Glycosylation | score3 | GlyGen UniProt | 23878260 | ||
| N515 | N-Glycosylation | score3 | GlyGen UniProt | 23878260 | ||
| T517 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N527 | N-Glycosylation | score2 | GlyGen UniProt | 16335952 | ||
| Y830 | Phosphorylation | P12931 (SRC) | score3 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 20431062 | |
| Y833 | Phosphorylation | P12931 (SRC) | score3 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 20431062 | |
| Y853 | Phosphorylation | P12931 (SRC) | score3 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 20431062 | |
| S863 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S871 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T886 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S976 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S986 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1063 | Phosphorylation | P35916 (FLT4) , P12931 (SRC) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 16076871, 25003617, 18083107, ... | |
| K1064 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y1068 | Phosphorylation | P35916 (FLT4) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 18083107, 25003617, 16076871, ... | |
| K1079 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1163 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1230 | Phosphorylation | P35916 (FLT4) , P35968 (KDR) | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 12881528, 16076871, 25643397 | |
| Y1231 | Phosphorylation | P35916 (FLT4) , P35968 (KDR) | score4 | neXtProt PhosphoSitePlus Signor UniProt | 12881528, 16076871 | |
| S1235 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1253 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y1265 | Phosphorylation | P35968 (KDR) , P35916 (FLT4) | score3 | neXtProt Signor UniProt | 12881528 | |
| K1300 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y1333 | Phosphorylation | P35916 (FLT4) , P35968 (KDR) , P12931 (SRC) | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 12881528, 20431062 | |
| Y1337 | Phosphorylation | P12931 (SRC) , P35916 (FLT4) | score4 | neXtProt PhosphoSitePlus RLIMS-P Signor UniProt | 12881528, 7675451, 16076871, ... | |
| Y1363 | Phosphorylation | P35916 (FLT4) | score3 | neXtProt Signor UniProt | 12881528 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T517 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y532 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y1230 | Phosphorylation | score1 | HPRD | 12881528 | ||
| Y1231 | Phosphorylation | score1 | HPRD | 12881528 | ||
| Y1265 | Phosphorylation | score1 | HPRD | 12881528 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T517 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y532 | Phosphorylation | score0 | HPRD | 20068231 | ||
| Y1230 | Phosphorylation | score1 | HPRD | 12881528 | ||
| Y1231 | Phosphorylation | score1 | HPRD | 12881528 | ||
| Y1265 | Phosphorylation | score1 | HPRD | 12881528 | ||
| Y1333 | Phosphorylation | score1 | HPRD | 7675451 | ||
| Y1337 | Phosphorylation | score2 | HPRD | 12881528, 7675451 | ||
| Y1363 | Phosphorylation | score2 | HPRD | 12881528, 7675451 |
P35916 (FLT4) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P29353 (SHC1) | Y349 | score3 | phospho.ELM Signor | 9927207 | |
| P29353 (SHC1) | Y350 | score3 | phospho.ELM Signor | 9927207 | |
| P29353 (SHC1) | Y427 | score3 | phospho.ELM Signor | 9927207 | |
| P35916 (FLT4) | Y1063 | score2 | UniProt | 16076871 | |
| P35916 (FLT4) | Y1068 | score2 | UniProt | 16076871 | |
| P35916 (FLT4) | Y1230 | score3 | neXtProt Signor UniProt | 12881528 | |
| P35916 (FLT4) | Y1231 | score3 | neXtProt Signor UniProt | 12881528 | |
| P35916 (FLT4) | Y1265 | score3 | neXtProt Signor UniProt | 12881528 | |
| P35916 (FLT4) | Y1333 | score3 | neXtProt Signor UniProt | 12881528 | |
| P35916 (FLT4) | Y1337 | score3 | neXtProt Signor UniProt | 12881528 | |
| P35916 (FLT4) | Y1363 | score3 | neXtProt Signor UniProt | 12881528 | |
| P51812 (RPS6KA3) | Y707 | score1 | Signor | 12601080 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| N33 | D33 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| N515 | S515 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T886 | M886 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S986 | W986 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| Y1063 | H1063 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| Y1068 | * | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] | |
| Y1068 | C1068 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| Y1230 | H1230 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S1235 | P1235 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K1253 | E1253 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y1333 | H1333 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
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