iPTMnet Report for P35908 (KRT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35908 / K22E_HUMAN
Protein Name Keratin, type II cytoskeletal 2 epidermal
Gene Name Name: KRT2
Synonyms:KRT2A,KRT2E;
Organism Homo sapiens (Human)

PRO ID PR:P35908
DAG View
PRO Name keratin, type II cytoskeletal 2 epidermal (human)
Definition A keratin, type II cytoskeletal 2 epidermal that is encoded in the genome of human.
Short Label hKRT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35908 (KRT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976
S75 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Methylation PhosphoSitePlus
K188 Sumoylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
R490 Methylation PhosphoSitePlus
R524 Methylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S536 Phosphorylation HPRD   PhosphoSitePlus 18691976
S546 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S557 O-Glycosylation GlyGen 33214551, 26853435, 29351928, ...34019948, 35083852, 28510447
S557 Phosphorylation HPRD   PhosphoSitePlus 18691976
Y563 Phosphorylation PhosphoSitePlus
S569 O-Glycosylation GlyGen 33214551, 26853435, 29351928, ...34019948, 35083852, 28510447
Y573 Phosphorylation PhosphoSitePlus
S579 O-Glycosylation GlyGen 33214551, 26853435, 29351928, ...34019948, 35083852, 28510447
S579 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
T635 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R122 C122 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R122 H122 Biomuta DOID:1324 / lung cancer [ cosmic ]
S191 F191 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y563 D563 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y563 C563 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S598 F598 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S621 Y621 Biomuta DOID:1324 / lung cancer [ cosmic ]
S637 C637 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]