iPTMnet Report for P35900 (KRT20)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35900 / K1C20_HUMAN
Protein Name Keratin, type I cytoskeletal 20
Gene Name Name: KRT20
Organism Homo sapiens (Human)

PRO ID PR:P35900
DAG View
PRO Name keratin, type I cytoskeletal 20 (human)
Definition A keratin, type I cytoskeletal 20 that is encoded in the genome of human.
Short Label hKRT20
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35900 (KRT20) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S13 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 16608857, 20724476
S13 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 16608857
S13 Phosphorylation P49137 (MAPKAPK2) neXtProt   PhosphoSitePlus 20724476
S34 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16083285
Y36 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
R45 Methylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
S94 Phosphorylation HPRD 20068231
S118 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
T168 Phosphorylation HPRD   PhosphoSitePlus 20068231
T369 Phosphorylation PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 R11 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R42 Q42 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R42 W42 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R45 H45 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R45 C45 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
K149 E149 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y370 C370 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S387 R387 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]