Protein Information

Cytoscape View

UniProt AC / UniProt ID P35813 / PPM1A_HUMAN
Protein Name Protein phosphatase 1A
Gene Name Name: PPM1A
Organism Homo sapiens (Human)

PRO ID PR:P35813
DAG View
PRO Name protein phosphatase 1A (human)
Definition A protein phosphatase 1A that is encoded in the genome of human.
Short Label hPPM1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P35813 (PPM1A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805, 20213681
K86 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T261 O-Glycosylation GlyGen 23301498, 29351928
K278 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
Y311 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus   UniProt 19690332
S377 Phosphorylation PhosphoSitePlus

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P28482 (MAPK1) S202 P35813 (PPM1A) unknown eFIP 23560844
Phosphorylation Q16539 (MAPK14) Y182 P35813 (PPM1A) unknown eFIP 23560844

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K98 R98 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Y362 C362 Biomuta DOID:0070003 / blastoma [ cosmic ]