iPTMnet Report for P35790 (CHKA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35790 / CHKA_HUMAN
Protein Name Choline kinase alpha
Gene Name Name: CHKA
Synonyms:CHK,CKI;
Organism Homo sapiens (Human)

PRO ID PR:P35790
DAG View
PRO Name choline kinase alpha (human)
Definition A choline kinase alpha that is encoded in the genome of human.
Short Label hCHKA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35790 (CHKA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K96 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y197 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 21822308
K247 Acetylation PhosphoSitePlus   UniProt 34077757
K258 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus   UniProt 34077757
Y333 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 21822308
T371 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
Y437 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus


P35790 (CHKA) as PTM Enzyme



Substrate Site Score Source PMID
O60664 (PLIN3) Y251 Signor 34929314
Q99541 (PLIN2) Y232 Signor 34929314


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35790 (CHKA) Y333 P00533 (EGFR) unknown eFIP 21822308


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K247 T247 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T371 I371 Biomuta DOID:4159 / skin cancer [ cosmic ]