Protein Information

Cytoscape View


UniProt AC / UniProt ID P35749 / MYH11_HUMAN
Protein Name Myosin-11
Gene Name Name: MYH11
Synonyms:KIAA0866;
Organism Homo sapiens (Human)

PRO ID PR:P35749
DAG View
PRO Name myosin-11 (human)
Definition A myosin-11 that is encoded in the genome of human.
Short Label hMYH11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35749 (MYH11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus   UniProt 24275569
S23 Phosphorylation PhosphoSitePlus   UniProt 24275569
K67 Acetylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K129 Methylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
K658 Methylation PhosphoSitePlus
T666 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
R718 Methylation PhosphoSitePlus
Y761 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
K767 Acetylation PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
Y826 Phosphorylation PhosphoSitePlus
K828 Acetylation PhosphoSitePlus
K828 Ubiquitination PhosphoSitePlus
K842 Ubiquitination PhosphoSitePlus
S883 Phosphorylation PhosphoSitePlus
T900 Phosphorylation PhosphoSitePlus
Y903 Phosphorylation PhosphoSitePlus
K968 Acetylation PhosphoSitePlus
K968 Ubiquitination PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
S1034 Phosphorylation PhosphoSitePlus
K1088 Acetylation PhosphoSitePlus
K1088 Ubiquitination PhosphoSitePlus
K1111 Acetylation PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus
T1153 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
T1162 Phosphorylation PhosphoSitePlus
S1189 Phosphorylation PhosphoSitePlus
K1216 Acetylation PhosphoSitePlus
K1226 Ubiquitination PhosphoSitePlus
K1256 Acetylation PhosphoSitePlus
S1266 Phosphorylation PhosphoSitePlus
T1336 Phosphorylation PhosphoSitePlus
S1347 O-Glycosylation GlyGen 23301498, 28411811, 29351928
S1347 Phosphorylation PhosphoSitePlus
S1367 Phosphorylation PhosphoSitePlus
T1368 Phosphorylation PhosphoSitePlus
K1377 Acetylation PhosphoSitePlus
K1378 Acetylation PhosphoSitePlus
K1395 Acetylation PhosphoSitePlus
T1405 Phosphorylation PhosphoSitePlus
Y1408 Phosphorylation PhosphoSitePlus
Y1415 Phosphorylation PhosphoSitePlus
T1421 Phosphorylation PhosphoSitePlus
S1444 Phosphorylation PhosphoSitePlus
K1448 Acetylation PhosphoSitePlus
K1449 Acetylation PhosphoSitePlus
K1452 Acetylation PhosphoSitePlus
K1452 Methylation PhosphoSitePlus
K1452 Ubiquitination PhosphoSitePlus
S1465 Phosphorylation PhosphoSitePlus
Y1467 Phosphorylation PhosphoSitePlus
K1484 Acetylation PhosphoSitePlus
K1484 Ubiquitination PhosphoSitePlus
S1487 Phosphorylation PhosphoSitePlus
T1558 Phosphorylation PhosphoSitePlus
K1562 Ubiquitination PhosphoSitePlus
Y1601 Phosphorylation PhosphoSitePlus
T1603 Phosphorylation PhosphoSitePlus
K1619 Acetylation PhosphoSitePlus
K1649 Acetylation PhosphoSitePlus
K1649 Ubiquitination PhosphoSitePlus
S1667 Phosphorylation PhosphoSitePlus
T1674 Phosphorylation PhosphoSitePlus
K1680 Acetylation PhosphoSitePlus
K1681 Acetylation PhosphoSitePlus
R1701 Methylation PhosphoSitePlus
K1731 Acetylation PhosphoSitePlus
S1810 Phosphorylation PhosphoSitePlus
K1811 Acetylation PhosphoSitePlus
K1813 Acetylation PhosphoSitePlus
S1814 Phosphorylation PhosphoSitePlus
T1815 Phosphorylation PhosphoSitePlus
Y1868 Phosphorylation PhosphoSitePlus
K1925 Methylation PhosphoSitePlus
S1954 Phosphorylation PhosphoSitePlus   UniProt 24275569, 18318008
T1958 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1960 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T604 Phosphorylation HPRD 18452278
S1814 Phosphorylation HPRD 20068231, 20068230
T1815 Phosphorylation HPRD 20068230
S1954 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
T611 Phosphorylation HPRD 18452278
S1821 Phosphorylation HPRD 20068231, 20068230
T1822 Phosphorylation HPRD 20068230
S1961 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
T611 Phosphorylation HPRD 18452278
S1821 Phosphorylation HPRD 20068231, 20068230
T1822 Phosphorylation HPRD 20068230
S1944 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T604 Phosphorylation HPRD 18452278
S1814 Phosphorylation HPRD 20068231, 20068230
T1815 Phosphorylation HPRD 20068230
S1937 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 I23 Biomuta DOID:1324 / lung cancer [ tcga ]
T208 K208 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T367 K367 Biomuta DOID:5041 / esophageal cancer [ tcga ]
T376 K376 Biomuta DOID:1115 / sarcoma [ tcga ]
K547 T547 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S638 L638 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ] DOID:3371 / chondrosarcoma [ cosmic ]
T666 I666 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R718 W718 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S883 L883 Biomuta DOID:3070 / malignant glioma [ tcga ]
S883 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1161 R1161 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K1216 N1216 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K1226 N1226 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1336 M1336 Biomuta DOID:363 / uterine cancer [ tcga ]
K1448 N1448 Biomuta DOID:1612 / breast cancer [ cosmic ]
K1449 Q1449 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1487 Y1487 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1487 C1487 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K1562 N1562 Biomuta DOID:3070 / malignant glioma [ tcga ]
K1562 E1562 Biomuta DOID:363 / uterine cancer [ tcga ]
T1603 M1603 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K1619 N1619 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S1667 F1667 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T1674 A1674 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K1811 E1811 Biomuta DOID:1909 / melanoma [ icgc, tcga ]