iPTMnet Report for P35712 (SOX6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35712 / SOX6_HUMAN
Protein Name Transcription factor SOX-6
Gene Name Name: SOX6
Organism Homo sapiens (Human)

PRO ID PR:P35712
DAG View
PRO Name transcription factor SOX-6 (human)
Definition A transcription factor SOX-6 that is encoded in the genome of human.
Short Label hSOX6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35712 (SOX6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
C87 Methylation IEDB 31844290
S98 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus   UniProt 23186163
S126 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S376 O-Glycosylation GlyGen 36240223
S380 O-Glycosylation GlyGen 36240223
S380 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus   UniProt 23186163
K404 Sumoylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
K417 Sumoylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus   UniProt 23186163
S442 Phosphorylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
R474 Methylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
Y671 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
T697 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S454 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T21 A21 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S106 I106 Biomuta DOID:1612 / breast cancer [ cosmic ]
S106 C106 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S376 T376 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S442 Y442 Biomuta DOID:363 / uterine cancer [ icgc ]
T444 I444 Biomuta DOID:4159 / skin cancer [ cosmic ]
S476 P476 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S678 R678 Biomuta [ cosmic ]
T697 I697 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T759 A759 Biomuta DOID:2394 / ovarian cancer [ cosmic ]