Protein Information

Cytoscape View


UniProt AC / UniProt ID P35711 / SOX5_HUMAN
Protein Name Transcription factor SOX-5
Gene Name Name: SOX5
Organism Homo sapiens (Human)

PRO ID PR:P35711
DAG View
PRO Name transcription factor SOX-5 (human)
Definition A transcription factor SOX-5 that is encoded in the genome of human.
Short Label hSOX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35711 (SOX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y23 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus   UniProt 24275569
S138 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T372 Phosphorylation PhosphoSitePlus   UniProt 24275569
S382 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus   UniProt 23186163
T413 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S424 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S441 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
K467 Sumoylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
S519 Phosphorylation phospho.ELM 18669648
S528 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
S534 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S538 Phosphorylation phospho.ELM 18669648
S540 Phosphorylation phospho.ELM 18669648
R549 Methylation PhosphoSitePlus
K595 Acetylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S519 Phosphorylation HPRD 18669648
S534 Phosphorylation HPRD 18669648
S538 Phosphorylation HPRD 18669648
S540 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S506 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 18669648
S525 Phosphorylation HPRD 18669648
S527 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation HPRD 18669648
S148 Phosphorylation HPRD 18669648
S152 Phosphorylation HPRD 18669648
S154 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T82 I82 Biomuta DOID:1909 / melanoma [ cosmic ]
T108 S108 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K171 T171 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S182 L182 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1115 / sarcoma [ icgc ]
S370 F370 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S370 P370 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T372 S372 Biomuta DOID:1324 / lung cancer [ tcga ]
S424 C424 Biomuta DOID:1324 / lung cancer [ tcga ]
S441 P441 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S503 T503 Biomuta DOID:1324 / lung cancer [ cosmic ]
S519 I519 Biomuta DOID:1324 / lung cancer [ tcga ]
S528 T528 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R549 H549 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R549 C549 Biomuta DOID:10283 / prostate cancer [ cosmic ]