iPTMnet Report for P35670 (ATP7B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35670 / ATP7B_HUMAN
Protein Name Copper-transporting ATPase 2
Gene Name Name: ATP7B
Synonyms:PWD,WC1,WND;
Organism Homo sapiens (Human)

PRO ID PR:P35670
DAG View
PRO Name copper-transporting ATPase 2 (human)
Definition A copper-transporting ATPase 2 that is encoded in the genome of human.
Short Label hATP7B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35670 (ATP7B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus   UniProt 23186163
S132 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 19520855, 23186163, 21189263
S478 Phosphorylation Q15139 (PRKD1) Signor 21189263
S481 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 19520855, 21189263
S481 Phosphorylation Q15139 (PRKD1) Signor 21189263
K489 Ubiquitination PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
T788 O-Glycosylation GlyGen 30379171, 29351928
K1028 Acetylation PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
T1050 Phosphorylation PhosphoSitePlus
T1076 Phosphorylation PhosphoSitePlus
Y1078 Phosphorylation PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus   Signor 21189263
S1121 Phosphorylation Q15139 (PRKD1) Signor 21189263
T1208 Phosphorylation PhosphoSitePlus
S1211 Phosphorylation PhosphoSitePlus
T1220 Phosphorylation PhosphoSitePlus
K1258 Acetylation PhosphoSitePlus
K1260 Acetylation PhosphoSitePlus
S1398 Phosphorylation PhosphoSitePlus
S1401 Phosphorylation PhosphoSitePlus
S1413 Phosphorylation PhosphoSitePlus
S1423 Phosphorylation PhosphoSitePlus
S1426 Phosphorylation PhosphoSitePlus
S1453 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 19520855, 21189263
S1453 Phosphorylation Q15139 (PRKD1) Signor 21189263


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T9 R9 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S23 C23 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S132 F132 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S348 F348 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K607 T607 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1050 I1050 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1260 N1260 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1401 G1401 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1413 Y1413 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]