Protein Information

Cytoscape View


UniProt AC / UniProt ID P35663 / CYLC1_HUMAN
Protein Name Cylicin-1
Gene Name Name: CYLC1
Synonyms:CYL,CYL1;
Organism Homo sapiens (Human)

PRO ID PR:P35663
DAG View
PRO Name cylicin-1 (human)
Definition A cylicin-1 that is encoded in the genome of human.
Short Label hCYLC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35663 (CYLC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y104 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K129 Acetylation PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
T161 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K286 Acetylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
K389 Acetylation PhosphoSitePlus
K396 Acetylation PhosphoSitePlus
K397 Acetylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K463 Acetylation PhosphoSitePlus
K466 Acetylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S188 F188 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S188 A188 Biomuta DOID:363 / uterine cancer [ tcga ]
S188 Y188 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K286 E286 Biomuta DOID:1909 / melanoma [ cosmic ]
K311 N311 Biomuta DOID:363 / uterine cancer [ tcga ]
S369 Y369 Biomuta DOID:1324 / lung cancer [ tcga ]
T370 P370 Biomuta DOID:1324 / lung cancer [ tcga ]
K396 N396 Biomuta DOID:1324 / lung cancer [ cosmic ]
K396 Q396 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S409 F409 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K459 N459 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K463 N463 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S541 L541 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S568 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K585 N585 Biomuta DOID:1909 / melanoma [ cosmic ]