iPTMnet Report for P35637 (FUS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35637 / FUS_HUMAN
Protein Name RNA-binding protein FUS
Gene Name Name: FUS
Synonyms:TLS;
Organism Homo sapiens (Human)

PRO ID PR:P35637
DAG View
PRO Name RNA-binding protein FUS (human)
Definition An RNA-binding protein FUS that is encoded in the genome of human.
Short Label hFUS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35637 (FUS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus   RLIMS-P 28790177
T11 Phosphorylation PhosphoSitePlus   RLIMS-P 28790177
T19 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T19 Phosphorylation PhosphoSitePlus   RLIMS-P 28790177
S26 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28790177, 18620545, 29897835
S26 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 18620545
S30 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28790177, 29897835
S39 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S42 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S42 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28790177, 18620545
S42 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 18620545
S42 Phosphorylation Q13315 (ATM) PhosphoSitePlus 18620545
T45 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
T47 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S54 Phosphorylation PhosphoSitePlus
S61 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 28790177, 18620545
S61 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 18620545
T68 Phosphorylation PhosphoSitePlus   RLIMS-P 28790177
S84 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 28790177, 18620545
S84 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 18620545
S87 Phosphorylation PhosphoSitePlus   RLIMS-P 28790177
S107 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S108 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
T109 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S110 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S112 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S112 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus   RLIMS-P 28790177
S131 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 28790177, 18620545
S131 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 18620545
S142 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
R213 Methylation PhosphoSitePlus
R216 Methylation PhosphoSitePlus   UniProt 24129315
R218 Methylation PhosphoSitePlus   UniProt 24129315
S221 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y232 Phosphorylation PhosphoSitePlus
R234 Methylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
R242 Methylation PhosphoSitePlus   UniProt 12964758
R244 Methylation PhosphoSitePlus   UniProt 12964758
R248 Methylation PhosphoSitePlus   UniProt 12964758
R251 Methylation PhosphoSitePlus   UniProt 12964758
S257 Phosphorylation phospho.ELM   PhosphoSitePlus 10913197
S257 Phosphorylation P05771-2 (PRKCB) PhosphoSitePlus 10913197
R259 Methylation PhosphoSitePlus   UniProt 12964758
K264 Ubiquitination PhosphoSitePlus
R269 Methylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus   UniProt 19690332
T286 Phosphorylation PhosphoSitePlus   UniProt 19690332
K312 Ubiquitination PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K316 Acetylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K332 Acetylation PhosphoSitePlus
K334 Sumoylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus   UniProt 23186163
S346 Phosphorylation PhosphoSitePlus
K348 Sumoylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K357 Acetylation PhosphoSitePlus
K357 Sumoylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K365 Methylation PhosphoSitePlus
K365 Sumoylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
R371 Methylation PhosphoSitePlus
R372 Methylation PhosphoSitePlus
R377 Methylation PhosphoSitePlus   UniProt 12964758
R383 Methylation UniProt 12964758
R386 Methylation UniProt 12964758
R388 Methylation UniProt 12964758
R394 Methylation PhosphoSitePlus   UniProt 12964758
Y397 Phosphorylation PhosphoSitePlus
R407 Methylation PhosphoSitePlus   UniProt 12964758
S412 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30397120, 34725712, 21740066, 29351928, 34019948, 36963488, 32119511, 34229054
S439 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
Y468 Phosphorylation PhosphoSitePlus
R473 Methylation PhosphoSitePlus   UniProt 12964758
R476 Methylation PhosphoSitePlus   UniProt 12964758
R481 Methylation PhosphoSitePlus   UniProt 12964758
R485 Methylation PhosphoSitePlus   UniProt 12964758
R487 Methylation PhosphoSitePlus   UniProt 12964758
R491 Methylation PhosphoSitePlus   UniProt 12964758
R495 Methylation PhosphoSitePlus   UniProt 12964758
R498 Methylation PhosphoSitePlus   UniProt 12964758
R503 Methylation PhosphoSitePlus   UniProt 24129315, 12964758
K510 Acetylation PhosphoSitePlus
R514 Methylation PhosphoSitePlus
R518 Methylation PhosphoSitePlus
R521 Methylation PhosphoSitePlus
R522 Methylation PhosphoSitePlus
R524 Methylation PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus   RLIMS-P 26403203
Y526 Phosphorylation P06241 (FYN) PhosphoSitePlus 26403203
Y526 Phosphorylation P12931 (SRC) PhosphoSitePlus 26403203
Site PTM Type PTM Enzyme Score Source PMID
S277 Phosphorylation HPRD 18452278
T286 Phosphorylation HPRD 18452278
Y304 Phosphorylation HPRD 20068231
T317 Phosphorylation HPRD 19651622, 20068231
Y325 Phosphorylation HPRD 19651622
T326 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
K333 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T11 I11 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S87 T87 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S108 N108 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S183 Y183 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R213 C213 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R216 H216 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R234 H234 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R244 C244 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R248 S248 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R259 L259 Biomuta DOID:1324 / lung cancer [ cosmic ]
K264 T264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R269 L269 Biomuta DOID:2021 / placenta cancer [ cosmic ]
T286 I286 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y304 H304 Biomuta DOID:363 / uterine cancer [ cosmic ]
K312 Q312 Biomuta DOID:1612 / breast cancer [ cosmic ]
K315 R315 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T338 M338 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S340 F340 Biomuta DOID:4159 / skin cancer [ cosmic ]
R371 C371 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
R372 Q372 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R377 W377 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R383 C383 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R383 H383 Biomuta DOID:1324 / lung cancer [ cosmic ]
R386 Q386 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R388 Q388 Biomuta DOID:184 / bone cancer [ cosmic ]
R394 H394 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R394 L394 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R394 C394 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S439 C439 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S439 F439 Biomuta DOID:4159 / skin cancer [ cosmic ]
K448 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S462 T462 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R473 C473 Biomuta DOID:4159 / skin cancer [ cosmic ]
R473 H473 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R481 * Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
R487 C487 Biomuta DOID:4159 / skin cancer [ cosmic ]
R495 L495 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R498 L498 Biomuta DOID:3571 / liver cancer [ cosmic ]
R498 Q498 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K510 N510 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R514 S514 Biomuta DOID:1324 / lung cancer [ cosmic ]
R518 I518 Biomuta DOID:363 / uterine cancer [ icgc ]
R521 H521 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R521 C521 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R522 S522 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]