iPTMnet Report for P35626 (GRK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35626 / ARBK2_HUMAN
Protein Name Beta-adrenergic receptor kinase 2
Gene Name Name: GRK3
Synonyms:ADRBK2,BARK2;
Organism Homo sapiens (Human)

PRO ID PR:P35626
DAG View
PRO Name beta-adrenergic receptor kinase 2 (human)
Definition A beta-adrenergic receptor kinase 2 that is encoded in the genome of human.
Short Label hGRK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35626 (GRK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
Y206 Phosphorylation PhosphoSitePlus
T213 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
T408 Phosphorylation IEDB 35494241
S423 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
Y526 Phosphorylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
Y564 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
K625 Acetylation PhosphoSitePlus
K628 Acetylation PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
N648 N-Glycosylation GlyGen 29741879
K652 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus


P35626 (GRK3) as PTM Enzyme



Substrate Site Score Source PMID
P07550 (ADRB2) S355 PhosphoSitePlus 25770216
P07550 (ADRB2) S356 PhosphoSitePlus 25770216
P21731-2 (TBXA2R) S239 PhosphoSitePlus 16956790
P21731-2 (TBXA2R) S357 PhosphoSitePlus 16956790
P30411 (BDKRB2) S366 Signor 11517230
P30411 (BDKRB2) S373 Signor 11517230
P30411 (BDKRB2) S375 Signor 11517230
P30874 (SSTR2) S341 PhosphoSitePlus 21330405
P30874 (SSTR2) S343 PhosphoSitePlus 21330405
P41146 (OPRL1) S363 PhosphoSitePlus 23086955
P51681 (CCR5) S336 PhosphoSitePlus 10085131
P51681 (CCR5) S337 PhosphoSitePlus 10085131
P51681 (CCR5) S342 PhosphoSitePlus 10085131
P51681 (CCR5) S349 PhosphoSitePlus 10085131


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K90 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K94 T94 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K138 N138 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K139 T139 Biomuta DOID:363 / uterine cancer [ icgc ]
K170 T170 Biomuta DOID:363 / uterine cancer [ icgc ]
K220 T220 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K345 N345 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y356 H356 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S423 F423 Biomuta DOID:4159 / skin cancer [ cosmic ]
K494 R494 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K497 N497 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K507 R507 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y526 D526 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y564 F564 Biomuta DOID:3571 / liver cancer [ cosmic ]