iPTMnet Report for P35612 (ADD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35612 / ADDB_HUMAN
Protein Name Beta-adducin
Gene Name Name: ADD2
Synonyms:ADDB;
Organism Homo sapiens (Human)

PRO ID PR:P35612
DAG View
PRO Name beta-adducin (human)
Definition A beta-adducin that is encoded in the genome of human.
Short Label hADD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35612 (ADD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y31 Phosphorylation PhosphoSitePlus
T55 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8810272
S60 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
Y489 Phosphorylation P06241 (FYN) PhosphoSitePlus   RLIMS-P 16765915
S512 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S532 Phosphorylation PhosphoSitePlus   UniProt 23186163
T533 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
K576 Acetylation PhosphoSitePlus
K583 Acetylation PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K595 Acetylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569
S600 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S604 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   UniProt 21406692, 21606488
T611 Phosphorylation PhosphoSitePlus   UniProt 21406692
S613 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   UniProt 21406692, 21606488, 23186163
S617 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   UniProt 21406692, 21606488, 23186163
S619 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus   UniProt 23186163
T626 Phosphorylation PhosphoSitePlus
T631 Phosphorylation PhosphoSitePlus
S632 Phosphorylation PhosphoSitePlus
T657 O-Glycosylation GlyGen 30379171
S663 O-Glycosylation GlyGen 30379171
T675 Phosphorylation PhosphoSitePlus   UniProt 23186163
K681 Acetylation PhosphoSitePlus
K683 Acetylation PhosphoSitePlus
T684 Phosphorylation PhosphoSitePlus
S693 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   UniProt 21406692, 21606488, 23186163
S697 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S699 Phosphorylation PhosphoSitePlus
S701 Phosphorylation Q00535 (CDK5) PhosphoSitePlus 21606488
S703 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 8810272
T711 Phosphorylation PhosphoSitePlus
S713 Phosphorylation O14757 (CHEK1) , P17612 (PRKACA) , Q05513 (PRKCZ) , P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15611095, 16116087, 21851590, ...8810272, 9679146
S718 Phosphorylation PhosphoSitePlus
S726 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P 16116087, 8810272, 9679146
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19651622
S532 Phosphorylation HPRD 19664994
T561 Phosphorylation HPRD 15345747
S592 Phosphorylation HPRD 18510355, 19413330
S596 Phosphorylation HPRD 18510355, 19413330, 19651622
S600 Phosphorylation HPRD 19413330, 19651622
S604 Phosphorylation HPRD 18510355, 19413330
S613 Phosphorylation HPRD 18510355
S617 Phosphorylation HPRD 18510355
S619 Phosphorylation HPRD 18510355
S621 Phosphorylation HPRD 18510355
S693 Phosphorylation HPRD 19413330, 19651622
S697 Phosphorylation HPRD 19413330, 19651622
S699 Phosphorylation HPRD 18510355, 19413330
S701 Phosphorylation HPRD 19651622
S703 Phosphorylation HPRD 18510355
S713 Phosphorylation Q05655 (PRKCD) , P17612 (PRKACA) HPRD 18452278, 8810272, 19664994, ...9679146
S718 Phosphorylation HPRD 18452278
S726 Phosphorylation Q05655 (PRKCD) , P17612 (PRKACA) HPRD 8810272, 9679146
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 19651622
S532 Phosphorylation HPRD 19664994
T561 Phosphorylation HPRD 15345747


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35612 (ADD2) Y489 P06241 (FYN) unknown eFIP 16765915


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 M5 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T5 A5 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S11 L11 Biomuta [ cosmic ]
Y31 C31 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S396 N396 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S396 R396 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S455 N455 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S512 T512 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S512 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S522 R522 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S530 R530 Biomuta DOID:1319 / brain cancer [ cosmic ]
S530 N530 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S592 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S596 Y596 Biomuta DOID:363 / uterine cancer [ icgc ]
S596 P596 Biomuta DOID:363 / uterine cancer [ icgc ]
S600 F600 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S621 F621 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T657 M657 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S663 N663 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T675 M675 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K681 M681 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S703 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S718 R718 Biomuta DOID:9256 / colorectal cancer [ cosmic ] [ cosmic, cosmic ]