iPTMnet Report for P35610 (SOAT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35610 / SOAT1_HUMAN
Protein Name Sterol O-acyltransferase 1
Gene Name Name: SOAT1
Synonyms:ACACT,ACACT1,ACAT;
Organism Homo sapiens (Human)

PRO ID PR:P35610
DAG View
PRO Name sterol O-acyltransferase 1 (human)
Definition A sterol O-acyltransferase 1 that is encoded in the genome of human.
Short Label hSOAT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35610 (SOAT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S8 Phosphorylation PhosphoSitePlus   UniProt 23186163
S14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
T36 O-Glycosylation GlyGen 29351928, 34725712, 35083852, ...28510447
T36 Phosphorylation PhosphoSitePlus
S38 O-Glycosylation GlyGen 29351928, 34725712, 35083852, ...28510447
S38 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
C345 Methylation IEDB 31844290
K353 Ubiquitination PhosphoSitePlus
C467 Methylation IEDB 31844290
K531 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S33 F33 Biomuta DOID:4159 / skin cancer [ cosmic ]
S71 N71 Biomuta DOID:1612 / breast cancer [ icgc ]
K120 N120 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K120 E120 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C345 Y345 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K353 R353 Biomuta DOID:3571 / liver cancer [ cosmic ]