iPTMnet Report for P35609 (ACTN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35609 / ACTN2_HUMAN
Protein Name Alpha-actinin-2
Gene Name Name: ACTN2
Organism Homo sapiens (Human)

PRO ID PR:P35609
DAG View
PRO Name alpha-actinin-2 (human)
Definition An alpha-actinin-2 that is encoded in the genome of human.
Short Label hACTN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35609 (ACTN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
C48 Methylation IEDB 31844290
K54 Ubiquitination PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
R83 Methylation PhosphoSitePlus
K86 Methylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
S147 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T151 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
C161 Methylation IEDB 31844290
K181 Acetylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
R268 Methylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
S431 O-Glycosylation GlyGen 30379171, 29351928, 35008409, ...23271734
S431 Phosphorylation PhosphoSitePlus
S433 Phosphorylation PhosphoSitePlus
T435 O-Glycosylation GlyGen 30379171, 29351928, 35008409, ...23271734
T435 Phosphorylation PhosphoSitePlus
K443 Acetylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
K499 Acetylation PhosphoSitePlus
K523 Acetylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
Y589 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
Y681 Phosphorylation PhosphoSitePlus
Y715 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
Y844 Phosphorylation PhosphoSitePlus
Y861 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y106 Phosphorylation HPRD 20068231
T495 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 N42 Biomuta DOID:1324 / lung cancer [ cosmic ]
K42 E42 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y106 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S147 L147 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K181 N181 Biomuta DOID:4159 / skin cancer [ cosmic ]
S201 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S250 C250 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R268 K268 Biomuta DOID:4159 / skin cancer [ cosmic ]
S291 C291 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T347 M347 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S355 C355 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S355 I355 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S431 L431 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S433 W433 Biomuta DOID:1324 / lung cancer [ cosmic ]
S433 L433 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T435 R435 Biomuta DOID:1324 / lung cancer [ cosmic ]
S449 R449 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K499 N499 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S596 R596 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S596 C596 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S840 F840 Biomuta DOID:1319 / brain cancer [ icgc ]
Y861 C861 Biomuta DOID:2394 / ovarian cancer [ cosmic ]