iPTMnet Report for P35556 (FBN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35556 / FBN2_HUMAN
Protein Name Fibrillin-2 precursor
Gene Name Name: FBN2
Organism Homo sapiens (Human)

PRO ID PR:P35556
DAG View
PRO Name fibrillin-2 (human)
Definition A fibrillin-2 that is encoded in the genome of human.
Short Label hFBN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35556 (FBN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T51 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K102 Sumoylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S298 O-Glycosylation GlyGen   UniProt 34411563
S340 O-Glycosylation GlyGen   UniProt 34411563
R362 Methylation PhosphoSitePlus
R374 Methylation PhosphoSitePlus
K385 Sumoylation PhosphoSitePlus
S516 O-Glycosylation GlyGen   UniProt 34411563
S555 O-Glycosylation GlyGen   UniProt 34411563
K570 Sumoylation PhosphoSitePlus
S597 O-Glycosylation GlyGen   UniProt 34411563
S638 O-Glycosylation GlyGen   UniProt 34411563
K644 Sumoylation PhosphoSitePlus
S679 O-Glycosylation GlyGen   UniProt 34411563
K711 Sumoylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K712 Sumoylation PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S832 O-Glycosylation GlyGen   UniProt 34411563
Y841 Phosphorylation PhosphoSitePlus
S872 O-Glycosylation GlyGen   UniProt 34411563
T923 Phosphorylation PhosphoSitePlus
S977 O-Glycosylation GlyGen   UniProt 34411563
K1019 Sumoylation PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
T1066 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K1072 Ubiquitination PhosphoSitePlus
K1078 Sumoylation PhosphoSitePlus
K1078 Ubiquitination PhosphoSitePlus
S1095 O-Glycosylation GlyGen   UniProt 34411563
N1112 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
S1137 O-Glycosylation GlyGen 34411563
S1180 O-Glycosylation GlyGen   UniProt 34411563
T1222 O-Glycosylation GlyGen   UniProt 34411563
S1263 O-Glycosylation GlyGen   UniProt 34411563
S1347 O-Glycosylation GlyGen   UniProt 34411563
S1390 O-Glycosylation GlyGen   UniProt 34411563
S1431 O-Glycosylation GlyGen 34411563
K1582 Sumoylation PhosphoSitePlus
K1582 Ubiquitination PhosphoSitePlus
S1672 O-Glycosylation GlyGen   UniProt 34411563
K1737 Sumoylation PhosphoSitePlus
N1745 N-Glycosylation GlyGen 24190977
N1756 N-Glycosylation GlyGen 24190977
K1774 Sumoylation PhosphoSitePlus
K1774 Ubiquitination PhosphoSitePlus
S1873 O-Glycosylation GlyGen   UniProt 34411563
T1951 O-Glycosylation GlyGen 34411563
S1954 O-Glycosylation GlyGen   UniProt 34411563
S1996 O-Glycosylation GlyGen   UniProt 34411563
K2112 Sumoylation PhosphoSitePlus
N2120 N-Glycosylation GlyGen 29741879
K2125 Acetylation PhosphoSitePlus
S2193 O-Glycosylation GlyGen   UniProt 34411563
S2274 O-Glycosylation GlyGen   UniProt 34411563
T2344 Phosphorylation PhosphoSitePlus
S2360 O-Glycosylation GlyGen   UniProt 34411563
K2435 Sumoylation PhosphoSitePlus
K2435 Ubiquitination PhosphoSitePlus
S2471 O-Glycosylation GlyGen   UniProt 34411563
S2512 O-Glycosylation GlyGen   UniProt 34411563
K2528 Sumoylation PhosphoSitePlus
K2528 Ubiquitination PhosphoSitePlus
K2531 Sumoylation PhosphoSitePlus
S2594 O-Glycosylation GlyGen   UniProt 34411563
S2675 O-Glycosylation GlyGen   UniProt 34411563
S2682 Phosphorylation PhosphoSitePlus
N2808 N-Glycosylation GlyGen 23090970, 24190977
K2861 Methylation PhosphoSitePlus
T2867 Phosphorylation PhosphoSitePlus
Y2868 Phosphorylation PhosphoSitePlus
T2869 Phosphorylation PhosphoSitePlus
T2873 Phosphorylation PhosphoSitePlus
S2874 Phosphorylation PhosphoSitePlus
Y2878 Phosphorylation PhosphoSitePlus
K2879 Methylation PhosphoSitePlus
K2885 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S298 Y298 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S298 P298 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R362 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R374 G374 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K385 T385 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S555 F555 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S597 N597 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S597 T597 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S679 F679 Biomuta DOID:4159 / skin cancer [ cosmic ]
S832 N832 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S977 Y977 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1078 E1078 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1078 R1078 Biomuta DOID:1319 / brain cancer [ icgc ]
K1078 T1078 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1137 R1137 Biomuta DOID:1319 / brain cancer [ icgc ]
S1137 G1137 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1347 F1347 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1582 N1582 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1582 T1582 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1737 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1873 T1873 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1996 Y1996 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2112 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K2112 N2112 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
N2120 S2120 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2193 Y2193 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2274 Y2274 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2274 P2274 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2344 N2344 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2435 N2435 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2471 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S2682 L2682 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N2808 S2808 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2867 A2867 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y2868 H2868 Biomuta DOID:3571 / liver cancer [ cosmic ]
T2869 A2869 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]