iPTMnet Report for P35555 (FBN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35555 / FBN1_HUMAN
Protein Name Fibrillin-1 precursor
Gene Name Name: FBN1
Synonyms:FBN;
Organism Homo sapiens (Human)

PRO ID PR:P35555
DAG View
PRO Name fibrillin-1 (human)
Definition A fibrillin-1 that is encoded in the genome of human.
Short Label hFBN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35555 (FBN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K54 Sumoylation PhosphoSitePlus
N57 N-Glycosylation GlyGen 29391424
N78 N-Glycosylation GlyGen 29391424
S115 Phosphorylation PhosphoSitePlus
C221 Methylation IEDB 31844290
R232 Methylation PhosphoSitePlus
S268 O-Glycosylation GlyGen   UniProt 34411563
K278 Sumoylation PhosphoSitePlus
C336 Methylation IEDB 31844290
S346 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
N448 N-Glycosylation GlyGen   UniProt 23090970, 19159218, 29391424, ...24190977
T450 O-Glycosylation GlyGen 35289036, 35254053
C453 Methylation IEDB 31844290
S471 O-Glycosylation GlyGen   UniProt 34411563
S510 O-Glycosylation GlyGen   UniProt 34411563
S552 O-Glycosylation GlyGen   UniProt 34411563
K568 Sumoylation PhosphoSitePlus
S593 O-Glycosylation GlyGen   UniProt 35289036, 35254053, 34411563
K599 Sumoylation PhosphoSitePlus
K612 Sumoylation PhosphoSitePlus
S634 O-Glycosylation GlyGen   UniProt 34411563
K666 Acetylation PhosphoSitePlus
K666 Sumoylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K672 Acetylation PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
S787 O-Glycosylation GlyGen   UniProt 34411563
K799 Sumoylation PhosphoSitePlus
K799 Ubiquitination PhosphoSitePlus
S827 O-Glycosylation GlyGen   UniProt 34411563
K904 Sumoylation PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
S932 O-Glycosylation GlyGen 34411563
C958 Methylation IEDB 31844290
Y962 Phosphorylation PhosphoSitePlus
C996 Methylation IEDB 31844290
K1017 Sumoylation PhosphoSitePlus
K1023 Sumoylation PhosphoSitePlus
K1027 Sumoylation PhosphoSitePlus
K1033 Sumoylation PhosphoSitePlus
S1037 Phosphorylation PhosphoSitePlus
K1043 Sumoylation PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
S1050 O-Glycosylation GlyGen   UniProt 34411563
N1067 N-Glycosylation GlyGen   UniProt 29741879, 29391424, 19159218
S1135 O-Glycosylation GlyGen   UniProt 34411563
C1208 Methylation IEDB 31844290
S1218 O-Glycosylation GlyGen   UniProt 34411563
C1263 Methylation IEDB 31844290
S1302 O-Glycosylation GlyGen   UniProt 34411563
K1317 Sumoylation PhosphoSitePlus
S1345 O-Glycosylation GlyGen   UniProt 34411563
N1369 N-Glycosylation GlyGen 23090970, 29741879, 24190977
S1386 O-Glycosylation GlyGen   UniProt 34411563
C1461 Methylation IEDB 31844290
N1484 N-Glycosylation GlyGen   UniProt 19159218
S1508 O-Glycosylation GlyGen   UniProt 34411563
Y1535 Phosphorylation PhosphoSitePlus
N1581 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
S1628 O-Glycosylation GlyGen   UniProt 34411563
C1631 Methylation IEDB 31844290
C1695 Methylation IEDB 31844290
N1703 N-Glycosylation GlyGen 29741879
N1713 N-Glycosylation GlyGen 30237853, 29391424
C1736 Methylation IEDB 31844290
S1830 O-Glycosylation GlyGen   UniProt 34411563
K1836 Sumoylation PhosphoSitePlus
S1871 O-Glycosylation GlyGen   UniProt 34411563
N1902 N-Glycosylation GlyGen 29741879
S1911 O-Glycosylation GlyGen   UniProt 34411563
S1953 O-Glycosylation GlyGen   UniProt 34411563
S2035 O-Glycosylation GlyGen   UniProt 34411563
S2047 Phosphorylation PhosphoSitePlus
S2048 Phosphorylation PhosphoSitePlus
S2049 Phosphorylation PhosphoSitePlus
K2064 Sumoylation PhosphoSitePlus
K2069 Sumoylation PhosphoSitePlus
S2148 O-Glycosylation GlyGen   UniProt 34411563
N2178 N-Glycosylation GlyGen 29741879
C2217 Methylation IEDB 31844290
S2227 O-Glycosylation GlyGen   UniProt 34411563
K2246 Sumoylation PhosphoSitePlus
T2297 Phosphorylation PhosphoSitePlus
K2298 Sumoylation PhosphoSitePlus
S2313 O-Glycosylation GlyGen   UniProt 34411563
C2339 Methylation IEDB 31844290
N2346 N-Glycosylation GlyGen 29391424
C2378 Methylation IEDB 31844290
K2387 Acetylation PhosphoSitePlus
K2388 Acetylation PhosphoSitePlus
K2388 Sumoylation PhosphoSitePlus
K2388 Ubiquitination PhosphoSitePlus
K2407 Sumoylation PhosphoSitePlus
S2465 O-Glycosylation GlyGen   UniProt 34411563
C2509 Methylation IEDB 31844290
S2547 O-Glycosylation GlyGen   UniProt 34411563
S2628 O-Glycosylation GlyGen   UniProt 34411563
S2702 Phosphorylation PhosphoSitePlus   UniProt 26091039, 24275569
S2709 Phosphorylation PhosphoSitePlus
S2711 O-Glycosylation GlyGen 30459171
N2767 N-Glycosylation GlyGen 23090970, 30237853, 29391424, ...24190977
T2788 Phosphorylation PhosphoSitePlus
K2805 Sumoylation PhosphoSitePlus
K2809 Sumoylation PhosphoSitePlus
S2813 Phosphorylation PhosphoSitePlus
K2821 Sumoylation PhosphoSitePlus
T2826 Phosphorylation PhosphoSitePlus
Y2827 Phosphorylation PhosphoSitePlus
S2832 Phosphorylation PhosphoSitePlus
T2834 Phosphorylation PhosphoSitePlus
Y2837 Phosphorylation PhosphoSitePlus
K2848 Sumoylation PhosphoSitePlus
Y2849 Phosphorylation PhosphoSitePlus
K2851 Sumoylation PhosphoSitePlus
Y2853 Phosphorylation PhosphoSitePlus
S2855 Phosphorylation PhosphoSitePlus
K2863 Sumoylation PhosphoSitePlus
K2865 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N1067 N-Glycosylation PRO 29741879
N1581 N-Glycosylation PRO 29741879
N1902 N-Glycosylation PRO 29741879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N57 D57 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
N78 K78 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R232 C232 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
R232 H232 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S268 F268 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S352 Y352 Biomuta DOID:1324 / lung cancer [ cosmic ]
S352 F352 Biomuta [ cosmic ]
S510 L510 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S552 G552 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K568 N568 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S593 I593 Biomuta DOID:363 / uterine cancer [ icgc ]
K666 M666 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K672 N672 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S932 L932 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C958 F958 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y962 N962 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1050 N1050 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1135 R1135 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1302 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1302 L1302 Biomuta DOID:4159 / skin cancer [ cosmic ]
C1695 Y1695 Biomuta DOID:1324 / lung cancer [ cosmic ]
C1695 F1695 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1911 F1911 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2047 P2047 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2049 T2049 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K2064 M2064 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2148 F2148 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2297 M2297 Biomuta DOID:363 / uterine cancer [ cosmic ]
S2313 N2313 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2387 N2387 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K2407 E2407 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C2509 Y2509 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S2628 I2628 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2709 L2709 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2709 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S2711 F2711 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2788 M2788 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2813 N2813 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2832 R2832 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T2834 I2834 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2834 A2834 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y2837 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K2848 R2848 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S2855 I2855 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K2865 E2865 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2865 Q2865 Biomuta DOID:2531 / hematologic cancer [ icgc ]