iPTMnet Report for P35520 (CBS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35520 / CBS_HUMAN
Protein Name Cystathionine beta-synthase
Gene Name Name: CBS
Organism Homo sapiens (Human)

PRO ID PR:P35520
DAG View
PRO Name cystathionine beta-synthase (human)
Definition A cystathionine beta-synthase that is encoded in the genome of human.
Short Label hCBS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35520 (CBS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
C15 S-Nitrosylation dbSNO 26338901
S19 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus   UniProt 21406692
S32 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
C109 S-Nitrosylation dbSNO 24105792
K119 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
R190 Methylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus   UniProt 23186163
K211 Sumoylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S227 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus   RLIMS-P 27509878, 26368121
S254 Phosphorylation PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
R336 Methylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
R389 Methylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K398 Sumoylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
T434 O-Glycosylation GlyGen 30459171
K481 Acetylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S525 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus 26368121
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 19413330
S32 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K72 I72 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K137 E137 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S199 F199 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R336 H336 Biomuta DOID:363 / uterine cancer [ icgc ]
R336 C336 Biomuta DOID:363 / uterine cancer [ icgc ]
T434 P434 Biomuta DOID:4159 / skin cancer [ cosmic ]