iPTMnet Report for P35498 (SCN1A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35498 / SCN1A_HUMAN
Protein Name Sodium channel protein type 1 subunit alpha
Gene Name Name: SCN1A
Synonyms:NAC1,SCN1;
Organism Homo sapiens (Human)

PRO ID PR:P35498
DAG View
PRO Name sodium channel protein type 1 subunit alpha (human)
Definition A sodium channel protein type 1 subunit alpha that is encoded in the genome of human.
Short Label hSCN1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35498 (SCN1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S480 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
T1066 Phosphorylation PhosphoSitePlus
K1506 Acetylation PhosphoSitePlus
Y1684 Phosphorylation PhosphoSitePlus
Y1694 Phosphorylation PhosphoSitePlus
T1908 Phosphorylation PhosphoSitePlus
T1909 Phosphorylation PhosphoSitePlus   RLIMS-P 30142967
S1918 Phosphorylation PhosphoSitePlus   RLIMS-P 30142967
Y1926 Phosphorylation PhosphoSitePlus
T1934 Phosphorylation PhosphoSitePlus   RLIMS-P 30142967
K1936 Acetylation PhosphoSitePlus
S1939 Phosphorylation PhosphoSitePlus
K1946 Acetylation PhosphoSitePlus
K1948 Acetylation PhosphoSitePlus
T1990 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1907 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S643 Phosphorylation PhosphoSitePlus
T644 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S586 Y586 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S643 T643 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S643 G643 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S652 F652 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S1060 N1060 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1063 F1063 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T1066 A1066 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1907 C1907 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T1908 A1908 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
T1909 N1909 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1918 C1918 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1939 F1939 Biomuta DOID:4159 / skin cancer [ cosmic ]