iPTMnet Report for P35372 (OPRM1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35372 / OPRM_HUMAN
Protein Name Mu-type opioid receptor
Gene Name Name: OPRM1
Synonyms:MOR1;
Organism Homo sapiens (Human)

PRO ID PR:P35372
DAG View
PRO Name mu-type opioid receptor (human)
Definition A mu-type opioid receptor that is encoded in the genome of human.
Short Label hOPRM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35372 (OPRM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y168 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus   Signor 10908300
S268 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 10908300
S270 Phosphorylation PhosphoSitePlus   Signor 10908300
S270 Phosphorylation Q9UQM7 (CAMK2A) Signor 10908300
Y338 Phosphorylation PhosphoSitePlus
T356 Phosphorylation Signor 12123746
T356 Phosphorylation P25098 (GRK2) Signor 12123746
S357 Phosphorylation Signor 12123746
S357 Phosphorylation P25098 (GRK2) Signor 12123746
S358 Phosphorylation Signor 12123746
S358 Phosphorylation P25098 (GRK2) Signor 12123746
S365 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus   Signor 10908300
T372 Phosphorylation Q9UQM7 (CAMK2A) Signor 10908300
S377 Phosphorylation PhosphoSitePlus 22375000
S377 Phosphorylation P25098 (GRK2) PhosphoSitePlus 22375000
T378 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T182 Phosphorylation HPRD 11060299
T356 Phosphorylation HPRD 12123746
S358 Phosphorylation HPRD 12123746
S365 Phosphorylation HPRD 11278523
T372 Phosphorylation HPRD 11278523
S377 Phosphorylation HPRD 11278523
T396 Phosphorylation HPRD 9312100
Site PTM Type PTM Enzyme Score Source PMID
T182 Phosphorylation HPRD 11060299
T182 Phosphorylation L0R4T6 (ADRBK2) HPRD 11060299
T356 Phosphorylation HPRD 12123746
T356 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 12123746
S358 Phosphorylation HPRD 12123746
S358 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 12123746
S365 Phosphorylation HPRD 11278523
T372 Phosphorylation HPRD 11278523
S377 Phosphorylation HPRD 11278523
Site PTM Type PTM Enzyme Score Source PMID
T182 Phosphorylation HPRD 11060299
T182 Phosphorylation L0R4T6 (ADRBK2) HPRD 11060299
T356 Phosphorylation HPRD 12123746
T356 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 12123746
S358 Phosphorylation HPRD 12123746
S358 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 12123746
S365 Phosphorylation HPRD 11278523
T372 Phosphorylation HPRD 11278523
S377 Phosphorylation HPRD 11278523
Site PTM Type PTM Enzyme Score Source PMID
T182 Phosphorylation HPRD 11060299
T182 Phosphorylation L0R4T6 (ADRBK2) HPRD 11060299
T356 Phosphorylation HPRD 12123746
T356 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 12123746
S358 Phosphorylation HPRD 12123746
S358 Phosphorylation A0A0S2Z3I6 (ADRBK1) HPRD 12123746
S365 Phosphorylation HPRD 11278523
T372 Phosphorylation HPRD 11278523
S377 Phosphorylation HPRD 11278523
K410 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S268 F268 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S270 F270 Biomuta DOID:4159 / skin cancer [ cosmic ]
T356 A356 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S357 F357 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S357 Y357 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S358 F358 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S365 F365 Biomuta DOID:4159 / skin cancer [ cosmic ]
T372 I372 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T378 M378 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T396 N396 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:8618 / oral cavity cancer [ cosmic, cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ]