iPTMnet Report for P35367 (HRH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35367 / HRH1_HUMAN
Protein Name Histamine H1 receptor
Gene Name Name: HRH1
Organism Homo sapiens (Human)

PRO ID PR:P35367
DAG View
PRO Name histamine H1 receptor (human)
Definition A histamine H1 receptor that is encoded in the genome of human.
Short Label hHRH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35367 (HRH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
T140 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15107581, 15328002
T140 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 15107581
T142 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15107581, 15328002
T142 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 15107581
S230 Phosphorylation PhosphoSitePlus   UniProt 23186163
S233 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S255 Phosphorylation HPRD   PhosphoSitePlus 18691976
K261 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S275 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
T279 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K284 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S380 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y386 Phosphorylation PhosphoSitePlus
S396 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15107581, 15328002
S396 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 15107581
S396 Phosphorylation P17612 (PRKACA) Signor 15328002
S396 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus 15107581
S396 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 15107581
S398 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15107581, 15328002, 10101032
S398 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 15107581, 10101032
S398 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor 15107581, 15328002
S398 Phosphorylation P25098 (GRK2) PhosphoSitePlus 15107581
S398 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus   Signor 15107581, 10101032
S398 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 15107581
Y401 Phosphorylation PhosphoSitePlus
T478 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15107581
T478 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 15107581


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 L70 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S233 F233 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K238 N238 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K238 R238 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T279 S279 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S285 Y285 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S396 P396 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S396 L396 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S396 W396 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]