iPTMnet Report for P35318 (ADM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35318 / ADML_HUMAN
Protein Name Pro-adrenomedullin precursor
Gene Name Name: ADM
Synonyms:AM;
Organism Homo sapiens (Human)

PRO ID PR:P35318
DAG View
PRO Name pro-adrenomedullin (human)
Definition A pro-adrenomedullin that is encoded in the genome of human.
Short Label hADM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35318 (ADM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S49 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S49 Phosphorylation PhosphoSitePlus
S50 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S51 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y52 Phosphorylation PhosphoSitePlus
T54 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T66 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
Y125 O-Glycosylation GlyGen 23584533, 25813380
T128 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K140 Ubiquitination PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
T162 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S165 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S178 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S180 O-Glycosylation GlyGen   PhosphoSitePlus 23584533


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y52 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y52 C52 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T128 I128 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S178 N178 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]