iPTMnet Report for P35270 (SPR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35270 / SPRE_HUMAN
Protein Name Sepiapterin reductase
Gene Name Name: SPR
Organism Homo sapiens (Human)

PRO ID PR:P35270
DAG View
PRO Name sepiapterin reductase (human)
Definition A sepiapterin reductase that is encoded in the genome of human.
Short Label hSPR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35270 (SPR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus   UniProt 23186163
S145 Phosphorylation PhosphoSitePlus
S213 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 11825621
S213 Phosphorylation Q13555 (CAMK2G) HPRD 11825621
S213 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 11825621
K226 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 F16 Biomuta DOID:4159 / skin cancer [ cosmic ]
S35 F35 Biomuta DOID:4159 / skin cancer [ cosmic ]
S103 Y103 Biomuta DOID:363 / uterine cancer [ icgc ]
S213 Y213 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K226 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K230 Q230 Biomuta DOID:4159 / skin cancer [ cosmic ]
K247 R247 Biomuta [ cosmic ]