iPTMnet Report for P35251 (RFC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35251 / RFC1_HUMAN
Protein Name Replication factor C subunit 1
Gene Name Name: RFC1
Synonyms:RFC140;
Organism Homo sapiens (Human)

PRO ID PR:P35251
DAG View
PRO Name replication factor C subunit 1 (human)
Definition A replication factor C subunit 1 that is encoded in the genome of human.
Short Label hRFC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35251 (RFC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K15 Acetylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
Y67 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648, 20068231
S69 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 19690332, 20068231, 17081983
S71 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 19690332, 20068231, 17081983
S73 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 17081983
T76 Phosphorylation PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
S108 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 20068231, ...24275569
T110 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S131 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
S156 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
T161 O-Glycosylation GlyGen 30379171, 34019948, 32522876, ...35289036
T161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...16565220
T163 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S164 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y168 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T171 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S173 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231, ...16565220
S177 Phosphorylation PhosphoSitePlus
S190 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...21406692, 18669648, 20068231
T193 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
T245 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
T272 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S281 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y282 Phosphorylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K323 Methylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S359 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S360 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S372 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K443 Acetylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K486 Acetylation PhosphoSitePlus
K488 Acetylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K498 Sumoylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
T506 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 12930972
K509 Acetylation PhosphoSitePlus
K514 Acetylation PhosphoSitePlus
S518 Phosphorylation P06493 (CDK1) PhosphoSitePlus 12930972
S520 Phosphorylation phospho.ELM 17081983
K551 Ubiquitination PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
K556 Sumoylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
K568 Sumoylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
C607 S-Nitrosylation dbSNO 26338901
K610 Acetylation PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K634 Acetylation PhosphoSitePlus
K638 Acetylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
K645 Methylation PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
Y670 Phosphorylation PhosphoSitePlus
Y672 Phosphorylation PhosphoSitePlus
K687 Ubiquitination PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K834 Ubiquitination PhosphoSitePlus
S909 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
R986 Methylation PhosphoSitePlus
K991 Acetylation PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
K1053 Ubiquitination PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
T1073 Phosphorylation PhosphoSitePlus
S1076 Phosphorylation PhosphoSitePlus
K1081 Ubiquitination PhosphoSitePlus
T1087 Phosphorylation PhosphoSitePlus
S1088 Phosphorylation PhosphoSitePlus
S1090 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus
Y1095 Phosphorylation PhosphoSitePlus
S1104 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1116 Phosphorylation PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
S1146 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y67 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20166139, 19415658, 20068231
S69 Phosphorylation HPRD 19413330, 16964243, 18767875, ...15302935, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S71 Phosphorylation HPRD 19413330, 16964243, 18767875, ...15302935, 19691289, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S73 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19691289, 19651622, 18669648, 20166139, 20068231, 17081983
T76 Phosphorylation HPRD 17081983
S99 Phosphorylation HPRD 20068231
T105 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 18669648, 15302935, 20068231, ...18452278
T110 Phosphorylation HPRD 18669648, 20068231, 18452278
S156 Phosphorylation HPRD 19651622, 18767875, 18669648, ...17081983, 20068231
T161 Phosphorylation HPRD 19651622, 18669648, 20068231, ...16565220
T163 Phosphorylation HPRD 18669648, 20068231
S164 Phosphorylation HPRD 18669648, 20068231
Y168 Phosphorylation HPRD 18669648, 20068231
T171 Phosphorylation HPRD 18669648, 20068231
S173 Phosphorylation HPRD 18669648, 20068231, 16565220
S190 Phosphorylation HPRD 18077418, 15302935, 19691289, ...18452278, 18669648, 20068231
T193 Phosphorylation HPRD 20068231
S281 Phosphorylation HPRD 18669648
S283 Phosphorylation HPRD 18669648, 20068231
S312 Phosphorylation HPRD 19413330, 18669648, 20068231
S359 Phosphorylation HPRD 18669648
S368 Phosphorylation HPRD 19651622, 18669648, 20068231
T506 Phosphorylation HPRD 20068231
S518 Phosphorylation HPRD 17081983, 20068231
S520 Phosphorylation HPRD 17081983
S1087 Phosphorylation HPRD 18452278
S1089 Phosphorylation HPRD 18452278
S1092 Phosphorylation HPRD 18452278
Y1094 Phosphorylation HPRD 18452278
S1103 Phosphorylation HPRD 18669648
S1105 Phosphorylation HPRD 19651622, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T33 S33 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S69 L69 Biomuta DOID:4159 / skin cancer [ cosmic ]
T76 M76 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S99 L99 Biomuta [ cosmic ] DOID:1540 / parathyroid carcinoma [ cosmic ]
S108 L108 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T171 A171 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S177 C177 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K243 E243 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K323 T323 Biomuta DOID:363 / uterine cancer [ icgc ]
S366 F366 Biomuta DOID:4159 / skin cancer [ cosmic ]
K468 Q468 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K486 R486 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K509 T509 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K556 R556 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K596 N596 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K834 T834 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S1146 L1146 Biomuta DOID:363 / uterine cancer [ icgc ]