iPTMnet Report for P35250 (RFC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35250 / RFC2_HUMAN
Protein Name Replication factor C subunit 2
Gene Name Name: RFC2
Organism Homo sapiens (Human)

PRO ID PR:P35250
DAG View
PRO Name replication factor C subunit 2 (human)
Definition A replication factor C subunit 2 that is encoded in the genome of human.
Short Label hRFC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35250 (RFC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
S18 Phosphorylation PhosphoSitePlus   UniProt 24275569
S30 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y34 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
R111 Methylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus   UniProt 19608861
K163 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
R184 Methylation PhosphoSitePlus
K192 Acetylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
C255 S-Nitrosylation dbSNO 19483679
K264 Ubiquitination PhosphoSitePlus
C270 Methylation IEDB 31844290
K304 Acetylation PhosphoSitePlus   UniProt 19608861
K318 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y190 Phosphorylation HPRD 20068231
T200 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K99 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation HPRD 20068231
T166 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R111 G111 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y161 H161 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S162 Y162 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S174 L174 Biomuta DOID:363 / uterine cancer [ icgc ]
R184 S184 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R184 C184 Biomuta DOID:4159 / skin cancer [ cosmic ]
C255 Y255 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K347 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]