iPTMnet Report for P35249 (RFC4)
Protein Information
| UniProt AC / UniProt ID | P35249 / RFC4_HUMAN |
| Protein Name | Replication factor C subunit 4 |
| Gene Name | Name: RFC4 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P35249 |
| PRO Name | replication factor C subunit 4 (human) |
| Definition | A replication factor C subunit 4 that is encoded in the genome of human. |
| Short Label | hRFC4 |
| Category | organism-gene |
P35249 (RFC4) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22814378 | ||
| K6 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K6 | Methylation | score1 | PhosphoSitePlus | |||
| K6 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S9 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S11 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K13 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K13 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T17 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K18 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R20 | Methylation | score1 | PhosphoSitePlus | |||
| S25 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S28 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K34 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K36 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K43 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K47 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C48 | Methylation | score1 | IEDB | 31844290 | ||
| K63 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R114 | Methylation | score1 | PhosphoSitePlus | |||
| K124 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K139 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T166 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T174 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T191 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K205 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K216 | Acetylation | score1 | PhosphoSitePlus | |||
| K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K217 | Acetylation | score1 | PhosphoSitePlus | |||
| K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K232 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T252 | O-Glycosylation | score1 | GlyGen | 23301498, 33214551, 30379171, ... | ||
| K255 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K260 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C281 | Methylation | score1 | IEDB | 31844290 | ||
| S285 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K288 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K322 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C337 | Methylation | score1 | IEDB | 31844290 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S9 | A9 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S9 | P9 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T17 | S17 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc, tcga ] | |
| R20 | L20 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S25 | G25 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K63 | N63 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| K64 | T64 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K84 | N84 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K139 | T139 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K200 | N200 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K232 | E232 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| K232 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S285 | C285 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K324 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| K324 | E324 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
DAG View