iPTMnet Report for P35240 (NF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35240 / MERL_HUMAN
Protein Name Merlin
Gene Name Name: NF2
Synonyms:SCH;
Organism Homo sapiens (Human)

PRO ID PR:P35240
DAG View
PRO Name merlin (human)
Definition A merlin that is encoded in the genome of human.
Short Label hNF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35240 (NF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation P31749 (AKT1) , P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 18071304, 21750658
S13 Phosphorylation PhosphoSitePlus   UniProt 23186163
K15 Sumoylation PhosphoSitePlus
C51 Methylation IEDB 31844290
K76 Sumoylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T230 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 17891137, 24166499, 19262146
K253 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S315 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 17891137, 24166499, 19262146
K322 Ubiquitination PhosphoSitePlus
R351 Methylation PhosphoSitePlus
R353 Methylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S518 Phosphorylation Q13153 (PAK1) , Q13177 (PAK2) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 14724586, 28919412, 16267393, ...17891137, 26481443, 17998937, 22325036, 18361411, 18835652, 19295124, 16247032, 18071304, 20890305, 19141242, 19262146, 17989580, 11719502, 24356468, 28972170, 24882693, 14981079, 25043298, 26045165, 17566081, 16324214, 20074368, 11782491, 17081983, 17175165, 33368671, 18669648, 15378014, 22105362, 27285107
K533 Ubiquitination PhosphoSitePlus
K550 Sumoylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
R568 Methylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
T576 Phosphorylation RLIMS-P 14724586, 16324214
K579 Ubiquitination PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus   RLIMS-P 22325036
S584 Phosphorylation RLIMS-P 22325036
K586 Ubiquitination PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus   RLIMS-P 22325036
Site PTM Type PTM Enzyme Score Source PMID
T477 Phosphorylation HPRD 20068231
S518 Phosphorylation Q13153 (PAK1) HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
Site PTM Type PTM Enzyme Score Source PMID
T477 Phosphorylation HPRD 20068231
S518 Phosphorylation Q13153 (PAK1) HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
Site PTM Type PTM Enzyme Score Source PMID
T394 Phosphorylation HPRD 20068231
S435 Phosphorylation Q13153 (PAK1) HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
Site PTM Type PTM Enzyme Score Source PMID
T436 Phosphorylation HPRD 20068231
S477 Phosphorylation Q13153 (PAK1) HPRD 19651622, 11719502, 18669648, ...20068231, 19691289
Site PTM Type PTM Enzyme Score Source PMID
T435 Phosphorylation HPRD 20068231
S476 Phosphorylation Q13153 (PAK1) HPRD 19651622, 11719502, 18669648, ...20068231, 19691289


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35240 (NF2) S518 P16070 (CD44) unknown eFIP 19141242
Phosphorylation P35240 (NF2) S518 Q9NRM7 (LATS2) unknown eFIP 33368671
Phosphorylation P35240 (NF2) S518 P46937 (YAP1) decreased_association eFIP 28972170
Phosphorylation P35240 (NF2) S315 Q99490 (AGAP2) inhibited_association eFIP 19262146
Phosphorylation P35240 (NF2) S518 Q16584 (MAP3K11) inhibited_association eFIP 20890305


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:P35240-1 (hNF2/iso:1) Interaction PR:Q9H204 (hMED28) PRO 15467741
PR:P35240-1 (hNF2/iso:1) Interaction PR:O14745 (hSLC9A3R1) PRO 9430655
PR:P35240-3 (hNF2/iso:2) Interaction PR:Q9H204 (hMED28) PRO 15467741
PR:P35240-4 (hNF2/iso:4) Interaction PR:P0DPB3-1 (hSCHIP1/iso:1) PRO 10669747


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 I10 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S13 Y13 Biomuta DOID:1324 / lung cancer [ cosmic ]
C51 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K80 R80 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K171 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T230 I230 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K253 N253 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K279 E279 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K289 * Biomuta DOID:3565 / meningioma [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S315 Y315 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K322 * Biomuta DOID:3565 / meningioma [ cosmic ]
R351 H351 Biomuta DOID:363 / uterine cancer [ cosmic ]
R351 C351 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K364 I364 Biomuta DOID:4159 / skin cancer [ cosmic ]
K364 E364 Biomuta [ cosmic ]
K387 E387 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T394 I394 Biomuta DOID:4159 / skin cancer [ cosmic ]
K401 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T419 M419 Biomuta DOID:363 / uterine cancer [ icgc ]
S435 A435 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T435 I435 Biomuta DOID:4159 / skin cancer [ cosmic ]
S435 F435 Biomuta DOID:4159 / skin cancer [ cosmic ]
T436 I436 Biomuta DOID:4159 / skin cancer [ cosmic ]
K449 * Biomuta [ cosmic ]
S476 A476 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S476 F476 Biomuta DOID:4159 / skin cancer [ cosmic ]
S477 F477 Biomuta DOID:4159 / skin cancer [ cosmic ]
T477 I477 Biomuta DOID:4159 / skin cancer [ cosmic ]
S477 A477 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S518 A518 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S518 F518 Biomuta DOID:4159 / skin cancer [ cosmic ]
K550 T550 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K579 N579 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K586 N586 Biomuta DOID:1612 / breast cancer [ cosmic ]