Protein Information

Cytoscape View


UniProt AC / UniProt ID P35237 / SPB6_HUMAN
Protein Name Serpin B6
Gene Name Name: SERPINB6
Synonyms:PI6,PTI;
Organism Homo sapiens (Human)

PRO ID PR:P35237
DAG View
PRO Name serpin B6 (human)
Definition A serpin B6 that is encoded in the genome of human.
Short Label hSERPINB6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35237 (SERPINB6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
Y42 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
R93 Methylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S151 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y168 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 V1 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
R89 K89 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
R93 W93 Biomuta DOID:1324 / lung cancer [ cosmic ]
S99 Y99 Biomuta DOID:3070 / malignant glioma [ tcga ]
K208 N208 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ cosmic ]