Protein Information

Cytoscape View


UniProt AC / UniProt ID P35236 / PTN7_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 7
Gene Name Name: PTPN7
Organism Homo sapiens (Human)

PRO ID PR:P35236
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 7 (human)
Definition A tyrosine-protein phosphatase non-receptor type 7 that is encoded in the genome of human.
Short Label hPTPN7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35236 (PTPN7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T23 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S44 Phosphorylation P17612 (PRKACA) , Q04759 (PRKCQ) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18088087, 10559944, 16479000, ...23186163, 19690332, 14613483
S54 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
T66 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18088087, 10206983, ...16441242
S93 Phosphorylation P28482 (MAPK1) , Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 10206983
K103 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus   UniProt 23186163
K122 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
Y149 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S246 Phosphorylation Q04759 (PRKCQ) PhosphoSitePlus 16479000
K248 Ubiquitination PhosphoSitePlus
S277 O-Glycosylation GlyGen 29351928
T298 O-Glycosylation GlyGen 29351928
K312 Ubiquitination PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S83 Phosphorylation P17612 (PRKACA) HPRD 20166139, 10559944
T105 Phosphorylation Q16539 (MAPK14) , P28482 (MAPK1) , P27361 (MAPK3) HPRD 18088087, 10206983
S132 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , Q16539 (MAPK14) HPRD 10206983
Site PTM Type PTM Enzyme Score Source PMID
S105 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R42 G42 Biomuta DOID:1324 / lung cancer [ cosmic ]
R42 W42 Biomuta DOID:1909 / melanoma [ cosmic ]
S110 N110 Biomuta DOID:1612 / breast cancer [ tcga ]
S143 I143 Biomuta DOID:10534 / stomach cancer [ icgc ]
T210 K210 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
S359 R359 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]