iPTMnet Report for P35232 (PHB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35232 / PHB1_HUMAN
Protein Name Prohibitin 1
Gene Name Name: PHB1
Synonyms:PHB;
Organism Homo sapiens (Human)

PRO ID PR:P35232
DAG View
PRO Name prohibitin 1 (human)
Definition A prohibitin 1 that is encoded in the genome of human.
Short Label hPHB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35232 (PHB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
K4 Acetylation IEDB   PhosphoSitePlus 34357683
K4 Methylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K11 Methylation PhosphoSitePlus
R41 Methylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus   UniProt 24275569
R93 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation P06213 (INSR) PhosphoSitePlus   RLIMS-P 19238206, 19497338, 22124450
S121 O-Glycosylation GlyGen   PhosphoSitePlus 30444036, 19238206, 34725712, ...33214551, 29351928, 35083852, 32119511
T123 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T141 O-Glycosylation GlyGen 30444036, 19238206, 34725712, ...33214551, 29351928, 35083852, 32119511
S151 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K202 Acetylation PhosphoSitePlus   UniProt 19608861
K202 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus   UniProt 24275569
S252 Phosphorylation phospho.ELM 17081983
S254 Phosphorylation phospho.ELM 17081983
T258 O-Glycosylation GlyGen   PhosphoSitePlus 30444036, 19238206, 34725712, ...33214551, 29351928, 35083852, 32119511
T258 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 25719244, 22410782, 32665357
Y259 Phosphorylation PhosphoSitePlus   RLIMS-P 19238206, 22410782
S265 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T80 Phosphorylation HPRD 20068231
Y249 Phosphorylation HPRD 20068231
S252 Phosphorylation HPRD 17081983
S254 Phosphorylation HPRD 17081983
S265 Phosphorylation HPRD 19007248


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35232 (PHB1) T258 P04049 (RAF1) unknown eFIP 29784973


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R41 Q41 Biomuta DOID:363 / uterine cancer [ icgc ]
R93 C93 Biomuta DOID:363 / uterine cancer [ icgc ]
S151 N151 Biomuta DOID:1319 / brain cancer [ icgc ]
S151 R151 Biomuta DOID:2394 / ovarian cancer [ icgc ]
K177 N177 Biomuta DOID:1781 / thyroid cancer [ icgc ]