Protein Information

Cytoscape View

UniProt AC / UniProt ID P35232 / PHB_HUMAN
Protein Name Prohibitin
Gene Name Name: PHB
Organism Homo sapiens (Human)

PRO ID PR:P35232
DAG View
PRO Name prohibitin (human)
Definition A prohibitin that is encoded in the genome of human.
Short Label hPHB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P35232 (PHB) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25944712
K4 Acetylation PhosphoSitePlus
K4 Methylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
K11 Methylation PhosphoSitePlus
R41 Methylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus   UniProt 24275569
R93 Methylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation P06213 (INSR) PhosphoSitePlus 19497338
S121 O-Glycosylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K202 Acetylation PhosphoSitePlus   UniProt 19608861
K202 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus   UniProt 24275569
S252 Phosphorylation phospho.ELM 17081983
S254 Phosphorylation phospho.ELM 17081983
T258 O-Glycosylation PhosphoSitePlus
T258 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 25719244, 22410782
Y259 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T80 Phosphorylation HPRD 20068231
Y249 Phosphorylation HPRD 20068231
S252 Phosphorylation HPRD 17081983
S254 Phosphorylation HPRD 17081983
S265 Phosphorylation HPRD 19007248

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35232 (PHB) T258 P04049 (RAF1) unknown eFIP 29784973

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K11 R11 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R41 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R41 Q41 Biomuta DOID:363 / uterine cancer [ tcga ]
S82 R82 Biomuta DOID:3571 / liver cancer [ icgc ]
R93 C93 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S101 R101 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T123 K123 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S151 R151 Biomuta DOID:2394 / ovarian cancer [ icgc ]
K177 N177 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S227 * Biomuta DOID:1115 / sarcoma [ tcga ]
K240 N240 Biomuta DOID:1324 / lung cancer [ tcga ]
S254 P254 Biomuta DOID:9256 / colorectal cancer [ tcga ]