iPTMnet Report for P35228 (NOS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35228 / NOS2_HUMAN
Protein Name Nitric oxide synthase, inducible
Gene Name Name: NOS2
Synonyms:NOS2A;
Organism Homo sapiens (Human)

PRO ID PR:P35228
DAG View
PRO Name nitric oxide synthase, inducible (human)
Definition A nitric oxide synthase, inducible that is encoded in the genome of human.
Short Label hNOS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35228 (NOS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S50 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16116474, 19875457
Y267 Phosphorylation PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
K604 Acetylation PhosphoSitePlus
R670 Methylation PhosphoSitePlus
S745 Phosphorylation P27361 (MAPK3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17804409
Y868 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
Y1055 Phosphorylation P12931 (SRC) PhosphoSitePlus 19875457
Y1123 Phosphorylation PhosphoSitePlus
Y1134 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S50 N50 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S70 C70 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S124 N124 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y267 N267 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y270 H270 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y451 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S453 Y453 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R670 H670 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R670 C670 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ icgc ]
S892 F892 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S898 F898 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S898 Y898 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y1055 C1055 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]