Protein Information

Cytoscape View


UniProt AC / UniProt ID P35222 / CTNB1_HUMAN
Protein Name Catenin beta-1
Gene Name Name: CTNNB1
Synonyms:CTNNB;ORFNames:OK/SW-cl.35,PRO2286;
Organism Homo sapiens (Human)

PRO ID PR:P35222
DAG View
PRO Name catenin beta-1 (human)
Definition A catenin beta-1 that is encoded in the genome of human.
Short Label hCTNNB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35222 (CTNNB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K19 Acetylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S23 O-Glycosylation GlyGen   UniProt 31346222, 26488919, 30397120, ...18586027, 23524144, 24342833, 12847106, 23552487, 30762425, 32149084, 17614351, 24744147, 28427939, 28657654, 26923859
S23 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29556045, 12027456
S29 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) , P19784 (CSNK2A2) HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12432063, 12027456, 26509276
Y30 Phosphorylation PhosphoSitePlus   RLIMS-P 28821617
S33 Phosphorylation Q9H2X6 (HIPK2) , O15111 (CHUK) , P49841 (GSK3B) , P45983 (MAPK8) , P49840 (GSK3A) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 30068336, 19061640, 32033025, ...28656063, 31355268, 19303846, 29337987, 25821199, 30530053, 19667122, 33641663, 31970420, 18070361, 30678307, 28518144, 27977752, 16996060, 20307497, 32571331, 21196815, 16618120, 11955436, 12051714, 33917100, 24938929, 24162018, 30854043, 22662165, 14500351, 27585692, 28658279, 15064718, 32046730, 31489935, 26509276, 30514931, 25647637, 30918250, 27462866, 26418878, 23471552, 21143984, 26905812, 26899563, 31731544, 25392450, 26098332, 30828563, 26908451, 25940701, 26000787, 25366337, 12000790, 23151663, 29354056, 25169422, 25546293, 23580348, 29212798, 27384483, 25691573, 16199882, 28209947, 26252009, 30258898, 22246988, 31714894, 26700621, 26910283, 25500543, 30016378, 20862283, 24829151, 17652946, 19060929, 15921235, 19293931, 22666492, 33987183, 23056571, 27661103, 26676402, 17260019, 24879546, 27551464, 33946505, 21829575, 11818547, 30150508, 29789528, 28808228, 30813948, 16293724, 32583737, 25058461, 12114015, 26246285, 32764573, 20717765, 14985333, 11967263, 28848389, 31555129, 29674637, 32294900, 27302922, 29441916, 28977889, 28191283, 27281614, 12417018, 32076059, 30926793, 28926590, 29351758, 29137254, 25514828, 16196383, 27374080, 30208924, 12799363, 22558232, 24501426, 30810286, 21986938, 32967262, 25639486, 27313491, 31068580, 33832512, 24930713, 31699039, 33239678, 28772205, 24704829, 30567741, 27835580, 19675674, 29445107, 33216839
S37 Phosphorylation P49840 (GSK3A) , P45983 (MAPK8) , Q9H2X6 (HIPK2) , P49841 (GSK3B) , O15111 (CHUK) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 30068336, 19061640, 32033025, ...28656063, 31355268, 19303846, 29337987, 25821199, 30530053, 19667122, 33641663, 31970420, 18070361, 30678307, 28518144, 27977752, 16996060, 25062958, 20307497, 32571331, 21196815, 16618120, 11955436, 12051714, 33917100, 24938929, 24162018, 30854043, 22662165, 14500351, 27585692, 28658279, 15064718, 32046730, 26509276, 30514931, 25647637, 30918250, 27462866, 26418878, 23471552, 26905812, 26899563, 31731544, 25392450, 26098332, 30828563, 26908451, 26000787, 26910375, 25366337, 12000790, 29354056, 21118991, 25546293, 23580348, 29212798, 27384483, 24743739, 25691573, 32398963, 16199882, 28209947, 26252009, 30258898, 22246988, 26700621, 26910283, 25500543, 26443198, 30016378, 20862283, 24829151, 19060929, 15921235, 19293931, 22666492, 33987183, 23056571, 26676402, 17260019, 24879546, 27551464, 33946505, 21829575, 11818547, 30150508, 29789528, 28808228, 30813948, 16293724, 32583737, 25058461, 20419129, 12114015, 26246285, 32764573, 20717765, 14985333, 11967263, 28848389, 31555129, 29674637, 32294900, 27302922, 24704829, 28977889, 28191283, 27281614, 12417018, 32076059, 30926793, 28926590, 29137254, 16196383, 27374080, 30208924, 12799363, 22558232, 24501426, 30810286, 32967262, 25639486, 27313491, 31068580, 33832512, 24930713, 31699039, 29556045, 33239678, 28772205, 29441916, 30567741, 27835580, 19675674, 33216839
T40 O-Glycosylation GlyGen 31346222, 26488919, 30397120, ...18586027, 23524144, 24342833, 12847106, 23552487, 30762425, 32149084, 17614351, 24744147, 28427939, 28657654, 26923859
T41 O-Glycosylation GlyGen 31346222, 26488919, 30397120, ...18586027, 23524144, 24342833, 12847106, 23552487, 30762425, 32149084, 17614351, 24744147, 28427939, 28657654, 26923859
T41 Phosphorylation P45983 (MAPK8) , O15111 (CHUK) , P49840 (GSK3A) , P49841 (GSK3B) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 17996206, 30068336, 32033025, ...28656063, 19303846, 25821199, 25058461, 19667122, 33641663, 31970420, 30678307, 27977752, 32099073, 25062958, 32571331, 21196815, 16618120, 12051714, 33917100, 32196848, 22662165, 14500351, 27585692, 11955436, 15064718, 32046730, 27462866, 30514931, 25647637, 21118991, 26509276, 26418878, 23471552, 21143984, 26905812, 26631736, 25392450, 26098332, 30828563, 26908451, 26000787, 31819794, 28887754, 12000790, 23151663, 15057752, 25401518, 25546293, 23580348, 27384483, 25691573, 32398963, 16199882, 29449807, 28209947, 26252009, 30258898, 22246988, 26700621, 26910283, 25500543, 25888911, 20862283, 24829151, 19060929, 15921235, 19293931, 22666492, 33987183, 23056571, 26676402, 17260019, 11818547, 27551464, 33946505, 21829575, 30150508, 29789528, 28808228, 30813948, 16293724, 32583737, 30530053, 20419129, 12114015, 26246285, 32764573, 20717765, 14985333, 11967263, 31555129, 29674637, 32294900, 27302922, 29441916, 28977889, 28191283, 27281614, 32076059, 28926590, 29137254, 16196383, 18070361, 12799363, 22558232, 24501426, 12027456, 32117718, 32967262, 25639486, 27313491, 31068580, 27733866, 33832512, 31699039, 29556045, 33239678, 28772205, 24704829, 30567741, 24039755, 27374080, 33216839
S45 Phosphorylation P48730 (CSNK1D) , P17612 (PRKACA) , P48729 (CSNK1A1) , P49674 (CSNK1E) , Q8N752 (CSNK1A1L) , O15111 (CHUK) , Q00534 (CDK6) , Q05513 (PRKCZ) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 32117718, 29674637, 18356165, ...23056571, 17208333, 25888911, 27653698, 12297048, 15064718, 26908451, 28191283, 21196815, 12417018, 26000787, 27158593, 32076059, 16199882, 31970420, 25660024, 22666492, 19244247, 12000790, 25514828, 26676402, 19293931, 32099073, 12799363, 16476742, 30150508, 16618120, 32549753, 21829575, 12176352, 25401518, 31934197, 25546293, 23580348, 24496450, 12051714, 30691485, 32196848, 21378377, 27733866, 24039755, 32041324, 28887754, 28977889, 32751567, 29468011, 29556045, 14500351, 27585692, 11955436, 20699366, 20419129, 32046730, 27462866, 11967263, 20717765, 26700621, 14985333, 33832512, 29387014, 17996206, 26509276, 23471552, 27374080, 29045831, 25500543, 27281614
S47 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus   UniProt 24824780
K49 Methylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation Q13882 (PTK6) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28821617, 20026641
S73 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation P00519 (ABL1) , P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 28821617, 11279024, 14517306, ...17318191, 10593980, 25500543
T102 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) , P67870 (CSNK2B) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 12432063, 26509276
T112 O-Glycosylation GlyGen 31346222, 26488919, 30397120, ...18586027, 23524144, 24342833, 12847106, 23552487, 30762425, 32149084, 17614351, 24744147, 28427939, 28657654, 26923859
T112 Phosphorylation Q15139 (PRKD1) , P67870 (CSNK2B) , P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22511927, 26509276, 19141652, ...26895471, 12432063
T120 Phosphorylation Q15139 (PRKD1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 29108267, 19141652, 26895471, ...22511927
S129 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation P22607 (FGFR3) , Q13882 (PTK6) , P21802 (FGFR2) , P04629 (NTRK1) , P06241 (FYN) , P16591 (FER) , P00533 (EGFR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24511551, 26509276, 17822871, ...18664491, 23641195, 15371335, 26654598, 17052462, 17113272, 22558232, 19501458, 12640114, 29415992, 20026641, 25500543
K158 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S191 Phosphorylation P45984 (MAPK9) , Q00535 (CDK5) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18578522, 26403202, 26509276, ...19664994, 21406692, 24257023, 18423204, 24275569, 18707149, 20166139, 17009320
S196 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S246 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 26509276, 17009320
K288 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation Q13882 (PTK6) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17087658, 20026641
T332 Phosphorylation Q9UQM7 (CAMK2A) , Q13554 (CAMK2B) PhosphoSitePlus   Signor 24117889
Y333 Phosphorylation P12931 (SRC) , Q13882 (PTK6) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26509276, 22056988, 20026641, ...17087658, 23178880
K335 Ubiquitination PhosphoSitePlus
K345 Acetylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K354 Acetylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
T393 Phosphorylation P68400 (CSNK2A1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 10806215, 12700239, 28733577, ...26509276
K394 Ubiquitination PhosphoSitePlus
K435 Acetylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
T472 Phosphorylation Q13554 (CAMK2B) , Q9UQM7 (CAMK2A) PhosphoSitePlus   Signor 24117889
S473 Phosphorylation PhosphoSitePlus   RLIMS-P 30374130
Y489 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P 17618275, 29355514, 27941077
K496 Ubiquitination PhosphoSitePlus
K508 Ubiquitination PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
C520 S-Nitrosylation dbSNO 24105792
T547 Phosphorylation PhosphoSitePlus
T551 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 19664995, 20068231, ...18220336
S552 Phosphorylation Q9UQM7 (CAMK2A) , P31751 (AKT2) , P17612 (PRKACA) , P54646 (PRKAA2) , Q13554 (CAMK2B) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32117718, 25514828, 32824435, ...32033025, 24117889, 28656063, 22520842, 25552486, 23618343, 28345588, 26908451, 30165890, 29415992, 25683913, 33641663, 27824126, 31082618, 25647637, 21406692, 25360740, 16199882, 18220336, 24365171, 23035229, 26565021, 25143352, 23785285, 32195176, 16476742, 24275569, 24930890, 29330435, 29050202, 22912335, 25500543, 30662060, 32827927, 23168683, 27384483, 21325624, 22692453, 32344885, 20058876, 19879273, 27698922, 24832083, 21649464, 29426364, 33832512, 23721711, 32860047, 26747727, 30854043, 33321112, 30841855, 33923707, 20361929, 17081983, 17287208, 30031230, 26715559, 19664995, 18353896, 26700621, 18669648, 28184024, 28671671, 30918250, 30258898, 20166139, 25544767, 20068231, 25217103
T556 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20058876, 18220336
T574 Phosphorylation HPRD   PhosphoSitePlus 20068231
S605 Phosphorylation P53778 (MAPK12) , P45984 (MAPK9) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 24257023, 18423204, 25961922, ...26403202
K625 Ubiquitination PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
T653 Phosphorylation PhosphoSitePlus
Y654 Phosphorylation P00533 (EGFR) , P07949 (RET) , P04626 (ERBB2) , P00519 (ABL1) , P36888 (FLT3) , P12931 (SRC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor 27782880, 18231728, 12740122, ...18316596, 21992464, 32848211, 9233779, 18553167, 29355514, 29415992, 32225105, 11245482, 22126602, 19336574, 25386896, 29311227, 24965120, 28938607, 23640056, 33188033, 28498415, 23246962, 18664491, 32231574, 28821617, 17143483, 19639172, 32308412, 17087658, 17318191, 27585692, 22480520, 28163245, 21423209, 23527294, 26509276, 10593980, 19101982, 11279024, 14517306, 28881682, 25500543
S663 Phosphorylation RLIMS-P 26509276
Y670 Phosphorylation PhosphoSitePlus   RLIMS-P 17087658, 33321112, 28938607, ...21423209
K671 Ubiquitination PhosphoSitePlus
S675 Phosphorylation O96013 (PAK4) , Q13153 (PAK1) , P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31900217, 33371405, 28470144, ...26908451, 28340578, 30165890, 21196815, 19581924, 25683913, 25143352, 29784906, 21822311, 28159572, 22369945, 18220336, 23552738, 28495797, 16476742, 29050202, 32967262, 26068882, 27313491, 28700668, 26780430, 21108734, 27698922, 29415992, 24352566, 29426364, 33832512, 26425687, 24930713, 22173096, 27624192, 16199882, 32102932, 27363012, 17081983, 26509276, 19664995, 28943877, 18353896, 26700621, 33321112, 17287208, 20166139, 29394407, 20068231, 25217103
T679 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S715 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   RLIMS-P   Signor 25639486
Y716 Phosphorylation PhosphoSitePlus
S718 Phosphorylation P53350 (PLK1) PhosphoSitePlus   RLIMS-P   Signor 19001871, 25639486
S721 Phosphorylation PhosphoSitePlus
Y724 Phosphorylation PhosphoSitePlus
Y748 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K19 Acetylation PR:000012332 (KAT2B) PRO 18987336
S33 Phosphorylation PR:P48729 (hCSNK1A1) , PR:P49841 (hGSK3B) PRO 11955436, 12000790, 16199882, ...14500351, 20307497
S37 Phosphorylation PR:P48729 (hCSNK1A1) , PR:P49841 (hGSK3B) , PR:P45983 (hMAPK8) PRO 11955436, 12000790, 14500351, ...20307497, 16199882, 19667122
T41 Phosphorylation PR:P48729 (hCSNK1A1) , PR:P49841 (hGSK3B) , PR:P45983 (hMAPK8) PRO 11955436, 12000790, 16199882, ...19667122, 14500351
S45 Phosphorylation PR:P49841 (hGSK3B) , PR:P48729 (hCSNK1A1) PRO 11955436, 12000790, 16199882
K49 Acetylation PR:000012332 (KAT2B) PRO 18987336
Y86 Phosphorylation PRO 11279024
S191 Phosphorylation PRO 17009320
S246 Phosphorylation PRO 17009320
Y333 Phosphorylation PRO 22056988
K345 Acetylation PR:000007102 (EP300) PRO 15060161
T393 Phosphorylation PRO 19565571, 12700239
S552 Phosphorylation PR:000029188 (cAMP-dependent protein kinase catalytic subunit) , PR:000029189 (AKT kinase) PRO 17287208, 16476742
Y654 Phosphorylation PR:P00533 (hEGFR) , PR:P12931 (hSRC) , PR:P04626 (hERBB2) PRO 11279024, 23640056
S663 Phosphorylation PR:000029188 (cAMP-dependent protein kinase catalytic subunit) , PR:000035776 (hPAK1/Phos:1) PRO 22369945
S675 Phosphorylation PR:000035776 (hPAK1/Phos:1) , PR:000029188 (cAMP-dependent protein kinase catalytic subunit) PRO 22369945, 16476742


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047098 (hCTNNB1/Phos:14) pS552 PRO
PR:000028553 (hCTNNB1/iso:1/Ac:1) acK345 PR:000007102 (EP300) PRO 15060161
PR:000028794 (hCTNNB1/iso:1/Ac:2) acK19,acK49 PR:000012332 (KAT2B) PRO 18987336
PR:000030192 (hCTNNB1/iso:1/Phos:1) pS663,pS675 PR:000029188 (cAMP-dependent protein kinase catalytic subunit) PRO 22369945
PR:000030192 (hCTNNB1/iso:1/Phos:1) pS663,pS675 PR:000035776 (hPAK1/Phos:1) PRO 22369945
PR:000035772 (hCTNNB1/iso:1/Phos:3) pS33,pS37,pT41,pS45 PR:P48729 (hCSNK1A1) PRO 11955436, 12000790, 16199882
PR:000035772 (hCTNNB1/iso:1/Phos:3) pS33,pS37,pT41,pS45 PR:P49841 (hGSK3B) PRO 11955436, 12000790, 16199882
PR:000035774 (hCTNNB1/iso:1/Phos:4) pS45 PR:P48729 (hCSNK1A1) PRO 11955436, 16199882
PR:000036862 (hCTNNB1/iso:1/Phos:5) pS552,pS675 PR:000029188 (cAMP-dependent protein kinase catalytic subunit) PRO 16476742
PR:000037181 (hCTNNB1/iso:1/Phos:6) pS37,pT41 PR:P45983 (hMAPK8) PRO 19667122
PR:000037190 (hCTNNB1/iso:1/Phos:7) pS33,pS37,pT41 PRO 14500351
PR:000037192 (hCTNNB1/iso:1/Phos:8) pY333 PRO 22056988
PR:000037194 (hCTNNB1/iso:1/Phos:9) pY86,pY654 PRO 11279024
PR:000037229 (hCTNNB1/iso:1/Phos:10) pS191,pS246 PRO 17009320
PR:000037515 (hCTNNB1/iso:1/Phos:11) pS33,pS37 PRO 20307497
PR:000044474 (hCTNNB1/iso:1/Phos:12) pT393 PRO 12700239, 19565571
PR:000044478 (hCTNNB1/iso:1/Phos:13) pY654 PR:P00533 (hEGFR) PRO 23640056
PR:000044478 (hCTNNB1/iso:1/Phos:13) pY654 PR:P04626 (hERBB2) PRO 23640056
PR:000044478 (hCTNNB1/iso:1/Phos:13) pY654 PR:P12931 (hSRC) PRO 23640056
PR:000044510 (hCTNNB1/iso:1/Phos:14) pS552 PR:000029189 (AKT kinase) PRO 17287208


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P12830 (CDH1) S846 P35222 (CTNNB1) decreased_association eFIP 23016862
Phosphorylation P35222 (CTNNB1) S552 P54646 (PRKAA2) unknown eFIP 30854043
Phosphorylation P35222 (CTNNB1) S191 Q9UJU2 (LEF1) increased_association eFIP 26403202
Phosphorylation P35222 (CTNNB1) S37 O95071 (UBR5) unknown eFIP 21118991
Phosphorylation P35222 (CTNNB1) S552 Q9UKT8 (FBXW2) unknown eFIP 30918250
Phosphorylation P35222 (CTNNB1) Y333 P14618 (PKM) unknown eFIP 22056988
Phosphorylation P35222 (CTNNB1) Y142 O00512 (BCL9) unknown eFIP 17052462
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) inhibited_association eFIP 22007144
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) decreased_association eFIP 25386896
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) decreased_association eFIP 11279024
Phosphorylation P35222 (CTNNB1) Y654 P12830 (CDH1) inhibited_association eFIP 31829231
Phosphorylation P35222 (CTNNB1) S675 Q15257 (PTPA) increased_association eFIP 28700668
Phosphorylation P35222 (CTNNB1) Y142 Q86UU0 (BCL9L) unknown eFIP 17052462
Phosphorylation P61586 (RHOA) Y42 P35222 (CTNNB1) unknown eFIP 33388549
Phosphorylation Q09472 (EP300) S89 P35222 (CTNNB1) increased_association eFIP 26833564
Phosphorylation Q9UJU2 (LEF1) S61 P35222 (CTNNB1) decreased_association eFIP 17113388


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035772 (hCTNNB1/iso:1/Phos:3) Interaction PR:Q9Y297 (hBTRC) PRO 10074433
PR:000035772 (hCTNNB1/iso:1/Phos:3) NOT Interaction PR:Q9UKB1 (hFBXW11) PRO 10074433
PR:000035774 (hCTNNB1/iso:1/Phos:4) Interaction PR:P12830 (hCDH1) PRO 20419129, 21152425
PR:000035774 (hCTNNB1/iso:1/Phos:4) increased Interaction PR:P49841 (hGSK3B) PRO 12051714, 20419129, 23606879
PR:000036862 (hCTNNB1/iso:1/Phos:5) increased Interaction PR:Q92793 (hCREBBP) PRO 16476742
PR:000037185 (hCTNNB1/iso:1/UnPhos:2) Interaction PR:P12830 (hCDH1) PRO 20419129
PR:000037190 (hCTNNB1/iso:1/Phos:7) increased Interaction PR:Q9Y297 (hBTRC) PRO 21152425
PR:000037190 (hCTNNB1/iso:1/Phos:7) decreased Interaction PR:Q9NQB0 (hTCF7L2) PRO 23617586
PR:000037190 (hCTNNB1/iso:1/Phos:7) decreased Interaction PR:P36402 (hTCF7) PRO 23617586
PR:000037190 (hCTNNB1/iso:1/Phos:7) NOT Interaction PR:P12830 (hCDH1) PRO 21152425
PR:000037190 (hCTNNB1/iso:1/Phos:7) decreased Interaction PR:Q9HCS4 (hTCF7L1) PRO 23617586
PR:000037190 (hCTNNB1/iso:1/Phos:7) decreased Interaction PR:Q9UJU2 (hLEF1) PRO 23617586
PR:000037192 (hCTNNB1/iso:1/Phos:8) Interaction PR:P14618 (hPKM) PRO 22056988
PR:000037194 (hCTNNB1/iso:1/Phos:9) increased Interaction PR:P20226 (hTBP) PRO 11279024
PR:000037194 (hCTNNB1/iso:1/Phos:9) decreased Interaction PR:P12830 (hCDH1) PRO 11279024
PR:000037515 (hCTNNB1/iso:1/Phos:11) increased Interaction PR:Q9Y297 (hBTRC) PRO 16996060, 21152425, 23071615
PR:000044474 (hCTNNB1/iso:1/Phos:12) decreased Interaction PR:Q9YGY0 (frog-axin) PRO 19565571
PR:000044476 (hCTNNB1/iso:1/UnPhos:7) Interaction PR:Q9YGY0 (frog-axin) PRO 19565571
PR:000044510 (hCTNNB1/iso:1/Phos:14) Interaction PR:P63104 (hYWHAZ) PRO 17287208


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 R23 Biomuta DOID:0070003 / blastoma [ cosmic ]
S23 N23 Biomuta DOID:0070003 / blastoma [ cosmic ]
S29 F29 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S29 A29 Biomuta DOID:3571 / liver cancer [ icgc ]
S29 Y29 Biomuta DOID:1909 / melanoma [ cosmic ]
S29 P29 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
Y30 C30 Biomuta DOID:0070003 / blastoma [ cosmic ]
S33 Y33 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ tcga ]
S33 T33 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S33 P33 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ]
S33 F33 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
S33 A33 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:5041 / esophageal cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S33 C33 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ]
S37 P37 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
S37 A37 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc, tcga ]
S37 C37 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic, tcga ] DOID:363 / uterine cancer [ tcga ] DOID:4362 / cervical cancer [ tcga ] DOID:10534 / stomach cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S37 Y37 Biomuta DOID:3571 / liver cancer [ tcga ] DOID:5041 / esophageal cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S37 T37 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S37 F37 Biomuta DOID:3571 / liver cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:5041 / esophageal cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:9256 / colorectal cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
T40 I40 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
T41 A41 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3571 / liver cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:1793 / pancreatic cancer [ tcga ] DOID:4362 / cervical cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3953 / adrenal gland cancer [ tcga ] DOID:263 / kidney cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
T41 S41 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:3963 / thyroid carcinoma [ cosmic ]
T41 I41 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ]
T41 N41 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ icgc ]
S45 F45 Biomuta DOID:3571 / liver cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ tcga ] DOID:3953 / adrenal gland cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S45 Y45 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S45 C45 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S45 P45 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:363 / uterine cancer [ cosmic ] DOID:1793 / pancreatic cancer [ tcga ] DOID:1909 / melanoma [ tcga ] DOID:3953 / adrenal gland cancer [ tcga ]
S45 T45 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S45 A45 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S47 C47 Biomuta DOID:0070003 / blastoma [ cosmic ]
S47 N47 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
S47 T47 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S47 G47 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S47 R47 Biomuta DOID:1909 / melanoma [ cosmic ]
K49 R49 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
K49 E49 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
K49 T49 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y86 H86 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
K158 E158 Biomuta DOID:363 / uterine cancer [ tcga ]
K170 M170 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S246 L246 Biomuta DOID:1612 / breast cancer [ icgc ]
Y333 F333 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:263 / kidney cancer [ cosmic ]
Y333 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K335 I335 Biomuta DOID:3571 / liver cancer [ tcga ] DOID:5041 / esophageal cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K335 T335 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc, tcga ] DOID:5041 / esophageal cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
K354 T354 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K354 * Biomuta DOID:5041 / esophageal cancer [ tcga ]
K394 N394 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K394 E394 Biomuta DOID:363 / uterine cancer [ tcga ]
K496 T496 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T510 P510 Biomuta DOID:363 / uterine cancer [ tcga ]
S646 C646 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S646 F646 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T653 K653 Biomuta DOID:10534 / stomach cancer [ tcga ]
T653 R653 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
S680 I680 Biomuta DOID:1909 / melanoma [ cosmic ]
S715 R715 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y716 C716 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]