iPTMnet Report for P35125 (USP6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35125 / UBP6_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 6
Gene Name Name: USP6
Synonyms:HRP1,TRE2;
Organism Homo sapiens (Human)

PRO ID PR:P35125
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 6 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 6 that is encoded in the genome of human.
Short Label hUSP6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35125 (USP6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y22 Phosphorylation PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
K578 Acetylation PhosphoSitePlus
K583 Acetylation PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
T1124 Phosphorylation PhosphoSitePlus
K1141 Acetylation PhosphoSitePlus
K1142 Acetylation PhosphoSitePlus
S1147 Phosphorylation phospho.ELM 18669648
K1158 Acetylation PhosphoSitePlus
S1159 Phosphorylation phospho.ELM 18669648
S1168 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation phospho.ELM 18669648
S1188 Phosphorylation PhosphoSitePlus
S1191 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
S1196 Phosphorylation PhosphoSitePlus
T1199 Phosphorylation PhosphoSitePlus
S1214 Phosphorylation PhosphoSitePlus
T1391 Phosphorylation PhosphoSitePlus
S1395 Phosphorylation PhosphoSitePlus
Y1399 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1147 Phosphorylation HPRD 18669648
S1159 Phosphorylation HPRD 18669648
S1169 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K645 M645 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1147 C1147 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1158 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T1199 I1199 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1391 M1391 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1395 F1395 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1399 N1399 Biomuta DOID:1324 / lung cancer [ cosmic ]