iPTMnet Report for P35080 (PFN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35080 / PROF2_HUMAN
Protein Name Profilin-2
Gene Name Name: PFN2
Organism Homo sapiens (Human)

PRO ID PR:P35080
DAG View
PRO Name profilin-2 (human)
Definition A profilin-2 that is encoded in the genome of human.
Short Label hPFN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35080 (PFN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
S6 Phosphorylation PhosphoSitePlus
Y7 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
R105 Methylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 18491316
Y7 Phosphorylation HPRD 18491316
Y99 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 18491316
Y7 Phosphorylation HPRD 18491316
Y99 Phosphorylation HPRD 18083107
T123 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
R136 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K126 N126 Biomuta DOID:9256 / colorectal cancer [ cosmic ]