Protein Information

Cytoscape View


UniProt AC / UniProt ID P34947 / GRK5_HUMAN
Protein Name G protein-coupled receptor kinase 5
Gene Name Name: GRK5
Synonyms:GPRK5;
Organism Homo sapiens (Human)

PRO ID PR:P34947
DAG View
PRO Name G protein-coupled receptor kinase 5 (human)
Definition A G protein-coupled receptor kinase 5 that is encoded in the genome of human.
Short Label hGRK5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34947 (GRK5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K24 Acetylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation P09619 (PDGFRB) neXtProt 19092051
Y109 Phosphorylation P09619 (PDGFRB) neXtProt 19092051
K113 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y251 Phosphorylation P12931 (SRC) RLIMS-P+ 21097543
Y253 Phosphorylation P12931 (SRC) RLIMS-P+ 21097543
Y309 Phosphorylation P09619 (PDGFRB) neXtProt 19092051
Y368 Phosphorylation P09619 (PDGFRB) neXtProt 19092051
Y408 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S484 Phosphorylation P34947 (GRK5) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 18669648, 20068231, ...8144599
T485 Phosphorylation P34947 (GRK5) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19651622, 18669648, 8144599
K487 Ubiquitination PhosphoSitePlus
K548 Methylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus


P34947 (GRK5) as PTM Enzyme



Substrate Site Score Source PMID
O75581 (LRP6) S1448 neXtProt 19801552
O75581 (LRP6) S1450 neXtProt 19801552
O75581 (LRP6) S1490 neXtProt 19801552
O75581 (LRP6) S1508 neXtProt 19801552
O75581 (LRP6) T1572 neXtProt 19801552
O75581 (LRP6) S1590 neXtProt 19801552
O75581 (LRP6) S1607 neXtProt 19801552
O76070 (SNCG) S124 HPRD   neXtProt 10852916, 18669648
P04637 (TP53) T55 neXtProt   PhosphoSitePlus   Signor 22223642, 20124405
P06748 (NPM1) S4 RLIMS-P+ 22467873
P07550 (ADRB2) S355 neXtProt   PhosphoSitePlus 20038610, 25770216, 18034461, ...14722251
P07550 (ADRB2) S356 neXtProt   PhosphoSitePlus 20038610, 25770216, 18034461, ...14722251
P07550 (ADRB2) T384 HPRD   neXtProt   PhosphoSitePlus 8662852
P07550 (ADRB2) T393 HPRD   neXtProt   PhosphoSitePlus 8662852
P07550 (ADRB2) S396 HPRD   neXtProt   PhosphoSitePlus 8662852
P07550 (ADRB2) S401 HPRD   neXtProt   PhosphoSitePlus 8662852
P07550 (ADRB2) S407 HPRD   neXtProt   PhosphoSitePlus 8662852
P07550 (ADRB2) S411 HPRD   neXtProt   PhosphoSitePlus 8662852
P25963 (NFKBIA) S32 neXtProt 19796012
P26038 (MSN) T66 RLIMS-P+ 24755472
P30411-1 (BDKRB2) S366 HPRD   Signor 11517230
P30411-1 (BDKRB2) S373 HPRD   Signor 11517230
P30411 (BDKRB2) S375 HPRD   Signor 11517230
P34947 (GRK5) S484 HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 20068231, ...8144599
P34947 (GRK5) T485 HPRD   PhosphoSitePlus   UniProt 19651622, 18669648, 8144599
P37840 (SNCA) S129 HPRD   neXtProt   PhosphoSitePlus   Signor 10852916, 10617630, 16957079
P49407 (ARRB1) S412 neXtProt 19661922
P50502 (ST13) S346 neXtProt   PhosphoSitePlus   Signor 21728385
P61073 (CXCR4) S339 RLIMS-P+ 24632620
Q16143 (SNCB) S118 HPRD   neXtProt 10852916


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K14 N14 Biomuta DOID:363 / uterine cancer [ tcga ]
K29 R29 Biomuta DOID:1909 / melanoma [ cosmic ]
Y90 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K113 T113 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K210 I210 Biomuta DOID:1324 / lung cancer [ tcga ]
K235 R235 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S484 F484 Biomuta DOID:4159 / skin cancer [ icgc ]
T485 I485 Biomuta DOID:3070 / malignant glioma [ tcga ]
T485 S485 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]