iPTMnet Report for P34925 (RYK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P34925 / RYK_HUMAN
Protein Name Tyrosine-protein kinase RYK precursor
Gene Name Name: RYK
Synonyms:JTK5A;
Organism Homo sapiens (Human)

PRO ID PR:P34925
DAG View
PRO Name tyrosine-protein kinase RYK (human)
Definition A tyrosine-protein kinase RYK that is encoded in the genome of human.
Short Label hRYK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34925 (RYK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K197 Sumoylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
R391 Methylation PhosphoSitePlus
K406 Methylation PhosphoSitePlus
K420 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T288 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T288 A288 Biomuta DOID:1324 / lung cancer [ cosmic ]
T300 S300 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T331 N331 Biomuta DOID:3571 / liver cancer [ cosmic ]
T340 A340 Biomuta DOID:4159 / skin cancer [ cosmic ]
K406 T406 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]