iPTMnet Report for P34913 (EPHX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P34913 / HYES_HUMAN
Protein Name Bifunctional epoxide hydrolase 2
Gene Name Name: EPHX2
Organism Homo sapiens (Human)

PRO ID PR:P34913
DAG View
PRO Name bifunctional epoxide hydrolase 2 (human)
Definition An epoxide hydrolase 2 that is encoded in the genome of human.
Short Label hEPHX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34913 (EPHX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Acetylation PhosphoSitePlus   UniProt 19608861
K43 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
K114 Acetylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K167 Acetylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T243 Phosphorylation IEDB 35494241
K245 Ubiquitination PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
Y308 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 R55 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K79 E79 Biomuta DOID:363 / uterine cancer [ icgc ]
K84 N84 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K167 T167 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K245 N245 Biomuta DOID:1324 / lung cancer [ cosmic ]
S299 L299 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K455 E455 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K474 T474 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K540 M540 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]