Protein Information

Cytoscape View


UniProt AC / UniProt ID P34896 / GLYC_HUMAN
Protein Name Serine hydroxymethyltransferase, cytosolic
Gene Name Name: SHMT1
Organism Homo sapiens (Human)

PRO ID PR:P34896
DAG View
PRO Name serine hydroxymethyltransferase, cytosolic (human)
Definition A serine hydroxymethyltransferase, cytosolic that is encoded in the genome of human.
Short Label hSHMT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34896 (SHMT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
Y34 Phosphorylation PhosphoSitePlus
K38 Sumoylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K39 Sumoylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
K274 Acetylation PhosphoSitePlus
K279 Acetylation PhosphoSitePlus
K375 Acetylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 20068231
Y34 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation HPRD 20068231
Y34 Phosphorylation HPRD 20068231
K271 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y73 * Biomuta DOID:3571 / liver cancer [ icgc ]
K157 * Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K158 N158 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K159 N159 Biomuta DOID:363 / uterine cancer [ tcga ]
Y183 S183 Biomuta DOID:1324 / lung cancer [ tcga ]
K449 M449 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]