iPTMnet Report for P34152 (Ptk2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P34152 / FAK1_MOUSE
Protein Name Focal adhesion kinase 1
Gene Name Name: Ptk2
Synonyms:Fadk,Fak,Fak1,Kiaa4203;
Organism Mus musculus (Mouse)

PRO ID PR:P34152
DAG View
PRO Name focal adhesion kinase 1 (mouse)
Definition A focal adhesion kinase 1 that is encoded in the genome of mouse.
Short Label mPTK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34152 (Ptk2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation PhosphoSitePlus   UniProt 21183079
T386 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 31831012, 22322421, 29472531, ...32612176, 25377086, 22887049, 32144580, 30250269, 30001432, 23571270, 11683393, 27708220, 24899686, 24888687, 29303405, 27009091, 29351412, 21289086, 21068464, 22204307, 27905395, 15592455, 28108732, 23695213, 11839767, 27374103, 10891511, 25242698, 32396631, 22285464, 11927607, 17303567, 12087088, 11314030, 32899862, 27306643, 27893716, 25692763, 19596799, 28444899, 23028449, 22919583, 19917775, 36438565, 16293639, 22105351, 10430888, 28701345, 8824286, 21921419, 29420611, 33917849, 27677358, 28782937, 28383553, 34240802, 29238610, 11279163, 11420674, 22279574, 17417603, 20886051, 20530207, 21347357, 28165007, 23693126, 28639351, 26378057, 33643917, 12083796, 35455022, 15845548, 17022972, 11468287, 30065303, 19776009, 7479864, 24124594, 23637231, 24755674, 25612833, 25100946, 21544092, 16132110, 7529876, 21823119, 15174091, 14500722, 15302877, 31882770, 24142503, 26068982, 27463003, 10806474, 28600496, 23613946, 24446483, 25280866, 33250856, 15967814, 31215459, 16972260, 15561106, 30717276, 25118939, 29416084, 28915654, 26340932, 23824717, 20737513, 9032297, 32642407, 27994061, 31604999, 32493400, 23642017, 26194913, 16337627, 24169345, 28416479, 28424421, 12515828, 26517238, 29528115, 10931187, 20234191, 20234193, 31942012, 10373530, 32025610, 17289681
Y397 Phosphorylation P34152 (Ptk2) UniProt 10373530
T406 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 17976369, 11420674, 17303567, ...7529876, 9790958
T408 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PhosphoSitePlus
Y576 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25377086, 23613946, 33250856, ...17242355, 17289681, 15561106, 24108461, 28915654, 21183079, 19917775, 27708220, 23027128, 26455318, 25938342, 23716717, 21289086, 28331230, 27905395, 7529876, 9790958, 16293639, 26908052, 26247733, 11420674, 10373530, 19098120, 18034455
Y577 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25377086, 23716717, 17242355, ...24108461, 28444899, 28915654, 11468287, 21183079, 27708220, 23027128, 26455318, 25938342, 33250856, 27905395, 7529876, 9790958, 16293639, 26247733, 11279163, 11420674, 10373530, 19098120, 18034455, 10497197
S705 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus   RLIMS-P 28331230
S732 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 12941275, 25609658
S840 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus   RLIMS-P 15845548
Y861 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 25377086, 23637231, 23799510, ...21289086, 12748308, 28444899, 11821402, 33730293, 28416479, 17289681, 15123632, 11927607, 16293639, 24169345, 11420674, 19000654, 23027128, 25242698
S910 Phosphorylation PhosphoSitePlus   RLIMS-P 28782937, 15845548, 32144580, ...15174091, 12692126
Y925 Phosphorylation IntAct   PhosphoSitePlus   RLIMS-P   UniProt 7997267, 22128142, 26378057, ...35325397, 27176481, 18356303, 22919583, 28255537, 22614008, 24108461, 28444899, 23028449, 25319025, 29209901, 9148935, 21535874, 27708220, 16293639, 23027128, 25938342, 9032297, 21289086, 8816475, 22974528, 29420611, 28915654, 24169345, 24416452, 28416479, 28424421, 16828471, 25063025, 16682956, 11420674, 11468287, 32655375, 18034455
Site PTM Type PTM Enzyme Score Source PMID
Y5 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
Y601 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
Y607 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
Y792 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
T886 Phosphorylation PhosphoSitePlus
Y892 Phosphorylation PhosphoSitePlus
S941 Phosphorylation PhosphoSitePlus
T945 Phosphorylation PhosphoSitePlus
Y956 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y397 Phosphorylation PhosphoSitePlus 7529876, 11279163
Y397 Phosphorylation P05480 (Src) PhosphoSitePlus 11279163
Y397 Phosphorylation P34152 (Ptk2) PhosphoSitePlus 7529876
Y407 Phosphorylation PhosphoSitePlus 7529876
Y407 Phosphorylation P05480 (Src) PhosphoSitePlus 7529876
Y576 Phosphorylation PhosphoSitePlus 7529876, 10672902, 9038154
Y576 Phosphorylation P05480 (Src) PhosphoSitePlus 7529876, 10672902, 9038154
Y577 Phosphorylation PhosphoSitePlus 7529876, 10672902, 11279163, ...9038154
Y577 Phosphorylation P05480 (Src) PhosphoSitePlus 7529876, 10672902, 11279163, ...9038154
S732 Phosphorylation PhosphoSitePlus 12941275
S732 Phosphorylation P49615 (Cdk5) PhosphoSitePlus 12941275
S843 Phosphorylation PhosphoSitePlus 15845548
S843 Phosphorylation P11798 (Camk2a) PhosphoSitePlus 15845548
S910 Phosphorylation PhosphoSitePlus 15174091, 12692126
S910 Phosphorylation P63085 (Mapk1) PhosphoSitePlus 12692126
S910 Phosphorylation Q63844 (Mapk3) PhosphoSitePlus 15174091
Site PTM Type PTM Enzyme Score Source PMID
T386 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
T917 Phosphorylation PhosphoSitePlus


P34152 (Ptk2) as PTM Enzyme



Substrate Site Score Source PMID
P34152 (Ptk2) Y397 PhosphoSitePlus   UniProt 7529876, 10373530
Q60598 (Cttn) Y421 PhosphoSitePlus 22952866
Q60598 (Cttn) Y466 PhosphoSitePlus 22952866
Q60598 (Cttn) Y482 PhosphoSitePlus 22952866
Q61140 (Bcar1) Y668 PhosphoSitePlus 11604500
Q91YD9 (Wasl) Y253 PhosphoSitePlus 14676198


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049944 (mPTK2/InitMet-/Phos:1) pY397 PRO 27994061


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P34152 (Ptk2) Y925 Q60631 (Grb2) increased_association eFIP 32655375
Phosphorylation P34152 (Ptk2) Y397 P05480 (Src) unknown eFIP 29238610
Phosphorylation P34152 (Ptk2) Y397 P05480 (Src) unknown eFIP 21823119