iPTMnet Report for P33993 (MCM7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33993 / MCM7_HUMAN
Protein Name DNA replication licensing factor MCM7
Gene Name Name: MCM7
Synonyms:CDC47,MCM2;
Organism Homo sapiens (Human)

PRO ID PR:P33993
DAG View
PRO Name DNA replication licensing factor MCM7 (human)
Definition A DNA replication licensing factor MCM7 that is encoded in the genome of human.
Short Label hMCM7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33993 (MCM7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
K4 Sumoylation PhosphoSitePlus
K4 Ubiquitination PhosphoSitePlus
Y6 Phosphorylation PhosphoSitePlus
K10 Sumoylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K15 Sumoylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
Y21 Phosphorylation PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
K28 Sumoylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K32 Sumoylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
C67 Methylation IEDB 31844290
K75 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S121 Phosphorylation P06493 (CDK1) , P24941 (CDK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 23720738, ...18669648, 20068231
K145 Ubiquitination PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K159 Sumoylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
K174 Sumoylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
R219 Methylation PhosphoSitePlus
R225 Methylation PhosphoSitePlus
K231 Sumoylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K236 Sumoylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K308 Sumoylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   UniProt 23186163
T320 Phosphorylation PhosphoSitePlus
R321 Methylation PhosphoSitePlus
R325 Methylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K351 Sumoylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S365 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 19647517, 20068231
K387 Ubiquitination PhosphoSitePlus
S388 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
R396 Methylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
R407 Methylation PhosphoSitePlus
K449 Methylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
C482 S-Nitrosylation dbSNO 24105792
Y492 Phosphorylation PhosphoSitePlus
S500 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...30784271, 19690332, 20068231
R524 Methylation PhosphoSitePlus
R527 Methylation PhosphoSitePlus
R532 Methylation PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S549 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K557 Ubiquitination PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
Y600 Phosphorylation P07948 (LYN) PhosphoSitePlus   RLIMS-P 23764002
T605 Phosphorylation PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
R673 Methylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus   UniProt 23186163
C684 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation HPRD 20068231
S113 Phosphorylation HPRD 20068231
S121 Phosphorylation HPRD 18691976, 18669648, 20068231
S309 Phosphorylation HPRD 19651622
T320 Phosphorylation HPRD 19651622
S365 Phosphorylation HPRD 20068231
S500 Phosphorylation HPRD 18691976, 18669648, 20068231
S549 Phosphorylation HPRD 17525332
T582 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S133 Phosphorylation HPRD 19651622
T144 Phosphorylation HPRD 19651622
S189 Phosphorylation HPRD 20068231
S324 Phosphorylation HPRD 18691976, 18669648, 20068231
S373 Phosphorylation HPRD 17525332
T406 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K29 T29 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K96 E96 Biomuta DOID:1319 / brain cancer [ cosmic ]
S113 N113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R219 W219 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R225 W225 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K231 N231 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K305 R305 Biomuta DOID:263 / kidney cancer [ cosmic ]
S373 F373 Biomuta DOID:4159 / skin cancer [ cosmic ]
K387 N387 Biomuta DOID:3571 / liver cancer [ cosmic ]
K387 E387 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S388 A388 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S388 C388 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S392 L392 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R396 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S401 T401 Biomuta DOID:263 / kidney cancer [ cosmic ]
R407 L407 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R524 L524 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R527 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R527 Q527 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R532 W532 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic ]
R532 Q532 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S549 F549 Biomuta DOID:4159 / skin cancer [ cosmic ]
K596 E596 Biomuta DOID:4159 / skin cancer [ cosmic ]
T599 I599 Biomuta DOID:4159 / skin cancer [ cosmic ]
T599 P599 Biomuta DOID:1612 / breast cancer [ cosmic ]
R673 Q673 Biomuta DOID:363 / uterine cancer [ icgc ]
R673 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]