iPTMnet Report for P33992 (MCM5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33992 / MCM5_HUMAN
Protein Name DNA replication licensing factor MCM5
Gene Name Name: MCM5
Synonyms:CDC46;
Organism Homo sapiens (Human)

PRO ID PR:P33992
DAG View
PRO Name DNA replication licensing factor MCM5 (human)
Definition A DNA replication licensing factor MCM5 that is encoded in the genome of human.
Short Label hMCM5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33992 (MCM5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378, 22223895
S2 Phosphorylation HPRD   PhosphoSitePlus 18491316
S12 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S130 Phosphorylation HPRD 20068231
S133 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S159 Phosphorylation HPRD   PhosphoSitePlus 20068231
C172 Methylation IEDB 31844290
K206 Ubiquitination PhosphoSitePlus
C207 Methylation IEDB 31844290
Y212 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
R251 Methylation PhosphoSitePlus
Y252 Phosphorylation IEDB 32387766
K256 Ubiquitination PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
R280 Methylation PhosphoSitePlus
S292 Phosphorylation IEDB 30784271
T303 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y332 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus
K387 Acetylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K392 Acetylation PhosphoSitePlus   UniProt 19608861
K392 Ubiquitination PhosphoSitePlus
K396 Acetylation PhosphoSitePlus   UniProt 19608861
K396 Ubiquitination PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
C482 S-Nitrosylation dbSNO 19483679
K499 Ubiquitination PhosphoSitePlus
R528 Methylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
C570 Methylation IEDB 31844290
K581 Acetylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus   UniProt 23186163
K625 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
T633 Phosphorylation PhosphoSitePlus 21851590
T633 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S693 Phosphorylation PhosphoSitePlus
K696 Acetylation PhosphoSitePlus   UniProt 19608861
K696 Ubiquitination PhosphoSitePlus
K702 Acetylation PhosphoSitePlus
K702 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K129 Q129 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S159 A159 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
C172 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K206 E206 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K273 R273 Biomuta DOID:1324 / lung cancer [ cosmic ]
T303 A303 Biomuta DOID:363 / uterine cancer [ icgc ]
K387 N387 Biomuta DOID:363 / uterine cancer [ icgc ]
Y403 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S423 L423 Biomuta DOID:4159 / skin cancer [ cosmic ]
C482 R482 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K583 Q583 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]